PMID: 9418256Jan 7, 1998Paper

Amplification of bacitracin transporter genes in the bacitracin producing Bacillus licheniformis

FEMS Microbiology Letters
Z PodlesekA Comino

Abstract

We have amplified the previously cloned and sequenced genes of the bacitracin exporter (bcr), a member of the ATP-binding transport protein family, within the chromosome of the bacitracin producing Bacillus licheniformis. Amplification of the transporter genes was followed by greatly increased bacitracin resistance. Antibiotic production was enhanced at a low level of bcr genes amplification. An enlarged increase in the copy number of the bcr genes negatively affects the overall growth of bacteria.

References

Jun 1, 1973·Journal of General Microbiology·H I Haavik, S Thomassen
May 10, 1974·Annals of the New York Academy of Sciences·A L Demain
Jan 1, 1995·FEMS Microbiology Letters·M TangneyS T Jørgensen
Jan 1, 1993·Annual Review of Biochemistry·M M Gottesman, I Pastan
Jan 20, 1996·Biotechnology and Bioengineering·P R ButlerS G Oliver

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Citations

Jun 1, 2000·Applied and Environmental Microbiology·K AltenaG Bierbaum
May 2, 2006·Biochemical and Biophysical Research Communications·Shimei WuLiandong Huan
Dec 18, 2013·Antimicrobial Agents and Chemotherapy·Susanne GebhardGregory M Cook
Jul 18, 2002·Journal of Inorganic Biochemistry·Li-June Ming, Jon D Epperson

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