Amplification of chirality of the majority-rules type in helical supramolecular polymers: the impact of the presence of achiral monomers

The Journal of Physical Chemistry. B
Jeroen van Gestel

Abstract

We present a theoretical treatment describing the conformational state of helical supramolecular polymers that consist of three types of monomer: right-handed and left-handed chiral monomers and achiral ones. We find that chirality amplification of the majority-rules type, that is, a disproportionately large shift in the helix screw sense due to a small enantiomeric excess, can occur in these polymers. The strength of the chirality amplification depends on the free-energy penalty of a helix reversal along the self-assembled chain and on that of a mismatch between the conformation of a bond and the preferred conformation of the preceding monomer. It turns out that the impact of achiral monomers also depends on these two parameters. For high values of these free energies, the net helicity does not change much from the situation where no achiral material is present. However, if the free-energy penalties are not both large, the impact of the achiral monomers on the conformational state of the aggregates can be quite substantial.

References

Jan 1, 1996·Physical Review Letters·J V Selinger, R L Selinger
Nov 11, 1999·Angewandte Chemie·M M GreenJ V Selinger
Mar 5, 2004·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Maria R D'Orsogna, Tom Chou
Jul 23, 2004·The Journal of Chemical Physics·Jeroen van GestelM A J Michels
Apr 14, 2005·Journal of the American Chemical Society·Jeroen van GestelE W Meijer

❮ Previous
Next ❯

Citations

Apr 30, 2011·Journal of the American Chemical Society·Francesca Di MariaGiovanna Barbarella
Dec 18, 2009·Journal of the American Chemical Society·Maarten M J SmuldersE W Meijer
Dec 18, 2009·Journal of the American Chemical Society·Maarten M J SmuldersE W Meijer
Oct 24, 2006·Chemical Communications : Chem Comm·Andrew J WilsonE W Meijer
Oct 6, 2006·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Penglei ChenMinghua Liu
Mar 3, 2011·Chemistry : a European Journal·Tomohiro SekiShiki Yagai
Jun 2, 2017·Macromolecular Rapid Communications·Dan-Wei ZhangZhan-Ting Li
Nov 13, 2009·Chemistry : a European Journal·Benjamin IsareLaurent Bouteiller
Sep 3, 2020·Advanced Materials·Xiaosheng YanYun-Bao Jiang

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.