Amplification of glutamate-induced oxidative stress

Toxicology Letters
K M SavolainenJ T Naarala

Abstract

Glutamate is a ubiquitous neurotransmitter which causes excess neuronal excitotoxicity and neurodegenerative insults such as stroke, trauma and seizures. A salient feature of the activation of glutamate receptors is the induction of oxidative burst. Moreover, glutamate stimulates Ca2+ influx and translocates protein kinase C (PKC). PKC mediates cellular processes mediated via phosphorylations which may be essential for oxidative burst in many cells. Subsequent oxidative stress may be a causal factor of neurodegenerative diseases. Increased glutamate release and oxidative burst may thus both be essential in the cascade of events leading to neuronal damage. Glutamate may also mediate neurotoxic effects of environmental toxic agents such as lead which amplify glutamate excitotoxicity. In these interactions, excessive activation of glutamate receptors and oxidative burst may converge into a common pathway leading to cell death through a cascade involving PKC or other protein important in oxidative burst in neurons.

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Citations

May 23, 2001·Progress in Neurobiology·N C Danbolt
May 10, 2000·Toxicology Letters·A L JadhavP G Gunasekar
Mar 22, 2002·The International Journal of Biochemistry & Cell Biology·José M MatésJavier Márquez
Nov 21, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Tatiana Wannmacher LepperLuciane Rosa Feksa
Sep 15, 2009·Toxicology Letters·Jian XuXiao-ming Shen
May 10, 2002·Depression and Anxiety·Eric Vermetten, J Douglas Bremner
May 30, 2001·Journal of Cataract and Refractive Surgery·P Sharma, A R Vasavada
Oct 4, 2020·Journal of Clinical Medicine·Stefania VernazzaSergio Claudio Saccà
May 16, 2021·Life Sciences·Xueqin WangChien-Liang Glenn Lin
Jul 3, 2021·Nutrients·Drake W LemPinakin Gunvant Davey

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