Amplification of inhibitory activity of catechin against disease-related enzymes by conjugation on poly(epsilon-lysine)

Biomacromolecules
Noriko IharaS Kobayashi

Abstract

A new inhibitor against disease-related enzymes, collagenase, hyaluronidase, and xanthine oxidase, has been developed by the laccase-catalyzed conjugation of catechin on poly(epsilon-lysine). The resulting poly(epsilon-lysine)-catechin conjugate showed greatly improved inhibition effects on activity of these enzymes, whereas the catechin monomer showed very low inhibition activity. The kinetic analysis on the inhibition of collagenase exhibited that the conjugate was a mixed-type inhibitor. The amplified activities might offer high potential as a therapeutic agent for prevention of various enzyme-related diseases.

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Citations

Jan 23, 2016·Chemical Reviews·Shin-ichiro ShodaShiro Kobayashi
May 29, 2014·Critical Reviews in Food Science and Nutrition·Giuseppe CirilloNevio Picci
Mar 22, 2015·Colloids and Surfaces. B, Biointerfaces·I Selestin Raja, Nishter Nishad Fathima
Aug 20, 2015·Biomacromolecules·Yu-Hsin LinChun-Lung Feng
Oct 19, 2016·Macromolecular Bioscience·Oleksandr ZagorodkoMaría J Vicent
Apr 13, 2007·Macromolecular Bioscience·Hiroshi Uyama
Jul 30, 2020·Polymers·Subhalakshmi NagarajanFerdinando Bruno
Oct 15, 2009·Chemical Reviews·Shiro Kobayashi, Akira Makino
Sep 10, 2014·Journal of Agricultural and Food Chemistry·Minhao XieXiaoxiong Zeng

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