Amplification of nitric oxide synthase expression by nitric oxide in interleukin 1 beta-stimulated rat mesangial cells

The Journal of Clinical Investigation
H Mühl, J Pfeilschifter

Abstract

Nitric oxide (NO) plays an important role in immunological reactions as a host defense mechanism against tumor cells and invasive microorganisms, but it may also damage healthy tissue. The excessive formation of NO in IL-1 beta-stimulated renal mesangial cells not only alters glomerular filtration, but it may also cause tissue injury and thus contribute to the pathogenesis of certain forms of glomerulonephritis. We report here that, although NO alone has no evident effect on NO synthase expression, it potently augments IL-1 beta-stimulated NO synthase expression in mesangial cells. NO donors such as sodium nitroprusside and S-nitroso-N-acetyl-D,L-penicillamine markedly increase IL-1 beta-induced NO synthase mRNA and protein levels as well as enzyme activity. Nuclear run-on experiments suggest that NO acts to increase IL-1 beta-induced NO synthase gene expression at the transcriptional level. Furthermore, inhibition of NO synthesis by different pharmacological approaches reduces IL-1 beta-induced NO synthase expression, thus suggesting that NO functions in a positive feedback loop that speeds up and strengthens its own biosynthesis. We suggest that this potent amplification mechanism forms the basis for the excessive formation o...Continue Reading

References

Jun 1, 1992·Current Opinion in Neurobiology·S H Snyder
May 1, 1992·Immunology Today·H Kolb, V Kolb-Bachofen
Dec 1, 1990·The Journal of Experimental Medicine·G Werner-FelmayerH Wachter
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·D KunzJ Pfeilschifter
Apr 1, 1994·Kidney International·A JansenV Cattell
May 1, 1994·British Journal of Pharmacology·H MühlJ Pfeilschifter
Mar 31, 1993·Biochemical and Biophysical Research Communications·M P ShermanL J Ignarro
Mar 1, 1993·British Journal of Pharmacology·J AssreuyS Moncada
May 14, 1994·Lancet·E Anggård
Oct 1, 1993·British Journal of Pharmacology·A IalentiM Di Rosa

❮ Previous
Next ❯

Citations

Feb 1, 1997·Arthritis and Rheumatism·T HayashiH E Jasin
May 9, 2000·Biochemical and Biophysical Research Communications·B HinzA Pahl
Sep 27, 2008·Apoptosis : an International Journal on Programmed Cell Death·Cristina NatalMaría J López-Zabalza
May 17, 2005·Nitric Oxide : Biology and Chemistry·Alan P KumarWanda F Reynolds
Jun 16, 1999·British Journal of Pharmacology·G RupprechtM Kaszkin
Jan 5, 2000·Kidney International·W EberhardtJ Pfeilschifter
Jan 12, 2002·Kidney International·Wolfgang EberhardtJosef Pfeilschifter
Jun 9, 2001·Antioxidants & Redox Signaling·D Pérez-Sala, S Lamas
Oct 28, 1999·American Journal of Respiratory Cell and Molecular Biology·I S YuhannaP W Shaul
May 1, 1996·The Journal of Clinical Investigation·T TetsukaA R Morrison
Dec 13, 2003·Biological Chemistry·Hartmut KleinertUlrich Förstermann
Dec 13, 2003·Biological Chemistry·Andrea Huwiler, Josef Pfeilschifter
Jul 7, 2009·Journal of the American Society of Nephrology : JASN·Ellen DreieicherJosef Pfeilschifter
Jan 5, 2011·Cellular Microbiology·Heiko MühlJosef Pfeilschifter
Mar 28, 2016·Critical Reviews in Oncology/hematology·Veena SomasundaramPriya Srinivas
Aug 27, 2005·Journal of Chemical Neuroanatomy·Alexander SemmlerMichael T Heneka
Dec 2, 2014·Biochemical Pharmacology·Karl-Friedrich BeckJosef Pfeilschifter
Feb 26, 2016·Antioxidants & Redox Signaling·Brian B RatliffMichael S Wolin
Mar 27, 2013·International Journal of Molecular Sciences·Subhashini Bolisetty, Edgar A Jaimes
Dec 4, 2003·Circulation Research·Renate B Pilz, Darren E Casteel
Apr 20, 2013·The Journal of Biological Chemistry·Martin Lee, Jonathan C Choy
Mar 22, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S WalpenJ Pfeilschifter
Feb 28, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Josef Pfeilschifter
Jul 17, 1999·The American Journal of Physiology·D W PowellA B West
May 4, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S FrankJ Pfeilschifter
Mar 29, 2014·Molecular and Cellular Biochemistry·Jelena ZlatkovićDragana Filipović
Feb 22, 2001·American Journal of Physiology. Renal Physiology·D Pérez-SalaS Lamas

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.