PMID: 8592214Nov 1, 1995Paper

Amplification of synaptic current by persistent sodium conductance in apical dendrite of neocortical neurons

Journal of Neurophysiology
P Schwindt, W Crill

Abstract

1. Evidence for amplification of synaptic current by voltage-gated channels in dendrites of neocortical pyramidal neurons was demonstrated by examining the effect of specific channel blocking agents on the current arriving at the soma during iontophoresis of glutamate at a distal site on the apical dendrite. 2. Dendritic noninactivating Na+ channels were implicated in this voltage-dependent amplification of the transmitted current because it was maintained for > 1 s and because tetrodotoxin (TTX) eliminated much of this amplification. 3. Specific blockers of N-methyl-D-aspartate (NMDA) glutamate receptors reduced the amplitude of the glutamate-evoked current at all potentials and also reduced the non-TTX-sensitive component of voltage-dependent augmentation. The effects of TTX were identical whether or not NMDA channels were blocked. 4. We conclude that a persistent Na+ conductance exists in the apical dendrite of neocortical neurons. Together with the NMDA conductance at the synaptic site it provides a mechanism for the graded, voltage-dependent amplification of tonic, excitatory synaptic input. This amplification results in much more effective transmission of tonic excitatory current to the soma than would occur in a passive ...Continue Reading

Citations

Oct 27, 1997·Journal of Neurophysiology·E P Cook, D Johnston
May 20, 1998·Journal of Neurophysiology·P C Schwindt, W E Crill
Jun 9, 1998·Annals of the New York Academy of Sciences·W E Crill
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·R Azouz, C M Gray
Oct 16, 2001·Journal of Neurophysiology·D J BennettM Siu
Nov 27, 2002·The Journal of General Physiology·Jacopo Magistretti, Angel Alonso
Mar 11, 2004·Journal of Integrative Neuroscience·Roman R Poznanski
Oct 16, 2004·Nature·Alain Destexhe, Eve Marder
May 11, 2005·Journal of Neurobiology·Allan T GulledgeGreg J Stuart
May 24, 2008·Journal of Neurophysiology·Diana Coomes PetersonJeffrey Wenstrup
May 7, 2010·Journal of Neurophysiology·Maurice J Chacron, Eric S Fortune
Jun 10, 2010·Nature Reviews. Neuroscience·R Angus Silver
Aug 31, 2012·Journal of Neurophysiology·Alessandro RossiFederica Ginanneschi
Sep 16, 2014·Frontiers in Psychology·Frédéric LavigneLaurent Dumercy
Dec 27, 2016·Frontiers in Systems Neuroscience·Asami TanimuraD James Surmeier
Aug 16, 2017·Biophysics Reviews·Cesar C CeballosRicardo M Leão
Dec 29, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Melissa S Haley, Arianna Maffei
May 2, 1998·Journal of Neurophysiology·T Mittmann, C Alzheimer
Dec 22, 1999·Journal of Neurophysiology·D B Jaffe, N T Carnevale
Apr 27, 2002·Journal of Neurophysiology·Drorit SaarEdi Barkai
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Oct 16, 2001·Journal of Neurophysiology·B DoironL Maler
Feb 22, 2001·Annual Review of Physiology·G W Davis, I Bezprozvanny
Oct 16, 2001·Journal of Neurophysiology·G González-Burgos, G Barrionuevo

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