Amplified fragment length polymorphism mapping of quantitative trait loci for malaria parasite susceptibility in the yellow fever mosquito Aedes aegypti.

Genetics
Daibin ZhongG Yan

Abstract

The yellow fever mosquito Aedes aegypti has been the subject of extensive genetic research due to its medical importance and the ease with which it can be manipulated in the laboratory. A molecular genetic linkage map was constructed using 148 amplified fragment length polymorphism (AFLP) and six single-strand conformation polymorphism (SSCP) markers. Eighteen AFLP primer combinations were used to genotype two reciprocal F2 segregating populations. Each primer combination generated an average of 8.2 AFLP markers eligible for linkage mapping. The length of the integrated map was 180.9 cM, giving an average marker resolution of 1.2 cM. Composite interval mapping revealed a total of six QTL significantly affecting Plasmodium susceptibility in the two reciprocal crosses of Ae. aegypti. Two common QTL on linkage group 2 were identified in both crosses that had similar effects on the phenotype, and four QTL were unique to each cross. In one cross, the four main QTL accounted for 64% of the total phenotypic variance, and digenic epistasis explained 11.8% of the variance. In the second cross, the four main QTL explained 66% of the variance, and digenic epistasis accounted for 16% of the variance. The actions of these QTL were either do...Continue Reading

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Citations

Oct 13, 2011·PLoS Neglected Tropical Diseases·Maria V SharakhovaIgor V Sharakhov
Mar 6, 2013·PLoS Neglected Tropical Diseases·Vladimir A TimoshevskiyMaria V Sharakhova
Feb 18, 2005·The Journal of Parasitology·Bruce M Christensen
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Mar 15, 2015·PloS One·Anastasia N NaumenkoMaria V Sharakhova
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Jun 24, 2017·Genetics·Yuelong GuoDahlia M Nielsen

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