Amplified Photoacoustic Signal and Enhanced Photothermal Conversion of Polydopamine-Coated Gold Nanobipyramids for Phototheranostics and Synergistic Chemotherapy

ACS Applied Materials & Interfaces
Yanhong LiuLeyong Zeng

Abstract

Light-responsive nanoprobes were suffering from the threat of high-dose laser irradiation, and it was important for constructing new nanoprobes for safe and efficient phototheranostics. Here, polydopamine (PDA)-coated gold nanobipyramids (AuNBPs@PDA) were synthesized for amplified photoacoustic (PA) signal and enhanced photothermal conversion with low-dose laser irradiation and then doxorubicin (DOX)-loaded AuNBPs@PDA-DOX nanoprobes were constructed for PA imaging-guided synergistic photothermal therapy (PTT) and chemotherapy. The AuNBPs@PDA nanoparticles possessed higher photothermal conversion efficiency (42.07%) and stronger PA signal than those of AuNBP nanoparticles, and the AuNBPs@PDA-DOX nanoprobes showed dual-responsive DOX release of pH and photothermal stimulation. With low-dose laser irradiation (1.0 W/cm2) and low-concentration AuNBPs@PDA-DOX (60 μg/mL), the 4T1 cell viability was reduced to about 5%, owing to the combination of PTT and chemotherapy, compared with 42.3% of single chemotherapy and 25.3% of single PTT. Moreover, by modeling 4T1 tumor-bearing nude mice, in vivo PA imaging was achieved and the tumors were completely inhibited, demonstrating the excellent synergistic effect of PTT/chemotherapy. Therefore...Continue Reading

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Citations

Aug 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Beibei LuJiaheng Zhang
Apr 11, 2020·Materials·Daniel HauserBarbara Rothen-Rutishauser
Sep 11, 2020·Acta Biomaterialia·Ariana S C GonçalvesIlídio J Correia
Jan 30, 2021·Frontiers in Microbiology·Indu SinghPradeep Kumar
Feb 27, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Jiahui LuJingjing Li
Feb 20, 2021·Nanotechnology·Mohammad Abdul-MoqueetKathryn M Mayer
Jun 2, 2021·Chemical Communications : Chem Comm·Jinyi DongQiangbin Wang
Nov 4, 2021·ACS Applied Materials & Interfaces·Peikun YanShujun Zhang

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