Amplified somatosensory and visual cortical projections to a core auditory area, the anterior auditory field, following early- and late-onset deafness

The Journal of Comparative Neurology
Carmen WongStephen G Lomber

Abstract

Cross-modal reorganization following the loss of input from a sensory modality can recruit sensory-deprived cortical areas to process information from the remaining senses. Specifically, in early-deaf cats, the anterior auditory field (AAF) is unresponsive to auditory stimuli but can be activated by somatosensory and visual stimuli. Similarly, AAF neurons respond to tactile input in adult-deafened animals. To examine anatomical changes that may underlie this functional adaptation following early or late deafness, afferent projections to AAF were examined in hearing cats, and cats with early- or adult-onset deafness. Unilateral deposits of biotinylated dextran amine were made in AAF to retrogradely label cortical and thalamic afferents to AAF. In early-deaf cats, ipsilateral neuronal labeling in visual and somatosensory cortices increased by 329% and 101%, respectively. The largest increases arose from the anterior ectosylvian visual area and the anterolateral lateral suprasylvian visual area, as well as somatosensory areas S2 and S4. Consequently, labeling in auditory areas was reduced by 36%. The age of deafness onset appeared to influence afferent connectivity, with less marked differences observed in late-deaf cats. Profound...Continue Reading

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Citations

Mar 10, 2016·The Laryngoscope·Jolie L ChangSteven W Cheung
Jun 6, 2016·Hearing Research·Melanie A Kok, Stephen G Lomber
Jun 14, 2016·Hearing Research·M Alex Meredith, Stephen G Lomber
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May 22, 2019·Journal of Cognitive Neuroscience·Caroline D C AlencarStephen G Lomber
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Mar 30, 2018·Frontiers in Behavioral Neuroscience·Yu-Chen ChenJian-Ping Gu
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Jan 3, 2021·The European Journal of Neuroscience·M Alex MeredithH Ruth Clemo
Apr 18, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Zixuan WeiLiang Chen

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