Amplitude-Integrated Electroencephalography for Early Recognition of Brain Injury in Neonates with Critical Congenital Heart Disease

The Journal of Pediatrics
Nathalie H P ClaessensLinda S de Vries

Abstract

To study perioperative amplitude-integrated electroencephalography (aEEG) as an early marker for new brain injury in neonates requiring cardiac surgery for critical congenital heart disease (CHD). This retrospective observational cohort study investigated 76 neonates with critical CHD who underwent neonatal surgery. Perioperative aEEG recordings were evaluated for background pattern (BGP), sleep-wake cycling (SWC), and ictal discharges. Spontaneous activity transient (SAT) rate, inter-SAT interval (ISI), and percentage of time with an amplitude <5 µV were calculated. Routinely obtained preoperative and postoperative magnetic resonance imaging of the brain were reviewed for brain injury (moderate-severe white matter injury, stroke, intraparenchymal hemorrhage, or cerebral sinovenous thrombosis). Preoperatively, none of the neonates showed an abnormal BGP (burst suppression or worse) or ictal discharges. Postoperatively, abnormal BGP was seen in 18 neonates (24%; 95% CI, 14%-33%) and ictal discharges was seen in 13 neonates (17%; 95% CI, 8%-26%). Abnormal BGP and ictal discharges were more frequent in neonates with new postoperative brain injury (P = .08 and .01, respectively). Abnormal brain activity (ie, abnormal BGP or ictal d...Continue Reading

Citations

Oct 30, 2019·World Journal for Pediatric & Congenital Heart Surgery·Kathleen R RyanAmy Jo Lisanti
Feb 8, 2020·Annals of Clinical and Translational Neurology·Xiao YuanChanglian Zhu
Sep 5, 2019·Current Opinion in Pediatrics·Brian R WhiteMatthew P Kirschen
Oct 1, 2019·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Pierre BourgoinAlexis Chenouard
Nov 7, 2019·Current Opinion in Pediatrics·Brian R WhiteMatthew P Kirschen
Jun 9, 2020·The Annals of Thoracic Surgery·Michael F SwartzGeorge M Alfieris
Feb 29, 2020·Pediatric Neurology·Cynthia M Ortinau, Joshua S Shimony
Feb 20, 2021·Frontiers in Neurology·Regina Trollmann
Mar 9, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robertino DilenaUNKNOWN INNESCO Group
Jul 27, 2021·Journal of Healthcare Engineering·Junjun ChenDianrong Wang

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