AMPs and OMPs: Is the folding and bilayer insertion of β-stranded outer membrane proteins governed by the same biophysical principles as for α-helical antimicrobial peptides?

Biochimica Et Biophysica Acta
Erik Strandberg, A S Ulrich

Abstract

The folding and function of membrane proteins is controlled not only by specific but also by unspecific interactions with the constituent lipids. In this review, we focus on the influence of the spontaneous lipid curvature on the folding and insertion of peptides and proteins in membranes. Amphiphilic α-helical peptides, as represented by various antimicrobial sequences, are compared with β-barrel proteins, which are found in the outer membrane of Gram-negative bacteria. It has been shown that cationic amphiphilic peptides are always surface-bound in lipids with a negative spontaneous curvature like POPC, i.e. they are oriented parallel to the membrane plane. On the other hand, in lipids like DMPC with a positive curvature, these peptides can get tilted or completely inserted in a transmembrane state. Remarkably, the folding and spontaneous membrane insertion of β-barrel outer membrane proteins also proceeds more easily in lipids with a positive intrinsic curvature, while it is hampered by negative curvature. We therefore propose that a positive spontaneous curvature of the lipids promotes the ability of a surface-bound molecule to insert more deeply into the bilayer core, irrespective of the conformation, size, or shape of the...Continue Reading

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Citations

Feb 9, 2016·Biochimica Et Biophysica Acta·Tatyana I RokitskayaOlga D Novikova
Jan 28, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Michael Richard SandersRebecca Joanne Green
Mar 11, 2016·The Journal of Physical Chemistry Letters·Ariadna Grau-CampistanyAnne S Ulrich
Mar 16, 2016·Biochimica Et Biophysica Acta·Héctor Zamora-CarrerasAnne S Ulrich
Oct 31, 2015·Biochimica Et Biophysica Acta·Richard M EpandNathan A Magarvey
Sep 7, 2016·Frontiers in Cell and Developmental Biology·Stephan L GrageAnne S Ulrich
Sep 23, 2016·Biophysical Journal·B Scott PerrinRichard W Pastor
Jan 5, 2016·PLoS Computational Biology·Almudena Pino-AngelesThemis Lazaridis
Oct 3, 2019·Physical Chemistry Chemical Physics : PCCP·Vladimir KubyshkinNediljko Budisa
Oct 17, 2017·Scientific Reports·Jonathan ZerweckAnne S Ulrich
Jan 28, 2021·The Journal of Antimicrobial Chemotherapy·Mário R FelícioSónia Gonçalves
Mar 4, 2020·Biochimica Et Biophysica Acta. Biomembranes·Erik StrandbergAnne S Ulrich
Nov 22, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Abraham Olusegun OluwoleSandro Keller
Mar 5, 2019·ACS Chemical Biology·Stéphane BaeriswylJean-Louis Reymond
Apr 19, 2018·Accounts of Chemical Research·Jakob P Ulmschneider, Martin B Ulmschneider
Jun 2, 2018·The Journal of Physical Chemistry. B·Erik StrandbergAnne S Ulrich
Aug 2, 2017·ACS Chemical Biology·Katharina StutzGisbert Schneider

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