Ampullary cancer of intestinal origin and duodenal cancer - A logical clinical and therapeutic subgroup in periampullary cancer

World Journal of Gastrointestinal Oncology
Manju D ChandrasegaramNeil D Merrett

Abstract

Periampullary cancers include pancreatic, ampullary, biliary and duodenal cancers. At presentation, the majority of periampullary tumours have grown to involve the pancreas, bile duct, ampulla and duodenum. This can result in difficulty in defining the primary site of origin in all but the smallest tumors due to anatomical proximity and architectural distortion. This has led to variation in the reported proportions of resected periampullary cancers. Pancreatic cancer is the most common cancer resected with a pancreaticoduodenectomy followed by ampullary (16%-50%), bile duct (5%-39%), and duodenal cancer (3%-17%). Patients with resected duodenal and ampullary cancers have a better reported median survival (29-47 mo and 22-54 mo) compared to pancreatic cancer (13-19 mo). The poorer survival with pancreatic cancer relates to differences in tumour characteristics such as a higher incidence of nodal, neural and vascular invasion. While small ampullary cancers can present early with biliary obstruction, pancreatic cancers need to reach a certain size before biliary obstruction ensues. This larger size at presentation contributes to a higher incidence of resection margin involvement in pancreatic cancer. Ampullary cancers can be subdi...Continue Reading

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Citations

Apr 4, 2019·International Journal of Surgical Pathology·Neha BakshiSunita Bhalla
May 1, 2020·Khirurgiia·E SerikulyB B Baymakhanov
Mar 25, 2020·World Journal of Gastrointestinal Oncology·Laura L MeijerGeert Kazemier
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Apr 1, 2020·Archives of Pathology & Laboratory Medicine·Xiaoyan Liao, Dongwei Zhang
May 11, 2021·Curēus·Rasiq ZackriaAndrew W Hwang
May 21, 2021·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Jana TesarikovaMartin Lovecek

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Methods Mentioned

BETA
exome sequencing

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