Amputation-free survival in 17,353 people at high risk for foot ulceration in diabetes: a national observational study

Diabetologia
Thenmalar VadivelooScottish Diabetes Research Network Epidemiology Group

Abstract

Our aim was to investigate amputation-free survival in people at high risk for foot ulceration in diabetes ('high-risk foot'), and to compare different subcategories of high-risk foot. Overall, 17,353 people with diabetes and high-risk foot from January 2008 to December 2011 were identified from the Scotland-wide diabetes register (Scottish Care Information-Diabetes: N = 247,278). Participants were followed-up for up to 2 years from baseline and were categorised into three groups: (1) those with no previous ulcer, (2) those with an active ulcer or (3) those with a healed previous ulcer. Participants with prior minor or major amputation were excluded. Accelerated failure time models were used to compare amputation-free survival up to 2 years between the three exposure groups. The 2 year amputation-free survival rate in all people with diabetes with high-risk foot was 84.5%. In this study group, 270 people (10.0%) had an amputation and 2424 (90.0%) died during the 2 year follow-up period. People who had active and healed previous ulcers at baseline had significantly lower 2 year amputation-free survival compared with those who had no previous ulcer (both p < 0.0001). The percentage of people who died within 2 years for those with...Continue Reading

References

Nov 1, 1995·Diabetes Care·L A LaveryT L Quebedeax-Farnham
Jul 27, 2001·Diabetes Care·E J PetersUNKNOWN International Working Group on the Diabetic FOot
May 25, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·C A AbbottUNKNOWN North-West Diabetes Foot Care Study
May 10, 2003·Lancet·William J Jeffcoate, Keith G Harding
May 4, 2005·The International Journal of Lower Extremity Wounds·Tammy Carlson, James F Reed
Sep 24, 2005·Diabetic Medicine : a Journal of the British Diabetic Association·N PoundW Jeffcoate
May 17, 2006·International Journal of Clinical Practice·G P LeeseA C Connacher
Sep 28, 2006·Diabetes Care·Christopher J SchofieldUNKNOWN DARTS/MEMO Collaboration
Mar 23, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·G P LeeseV Green
Jul 23, 2014·Yonsei Medical Journal·Sung Hun WonKyoung Min Lee
Jul 24, 2015·Diabetes Care·Ole HoffstadDavid J Margolis
Oct 13, 2015·Diabetes/metabolism Research and Reviews·Frances Game
Mar 16, 2016·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Solène Schirr-BonnansLaurent Molinier
Mar 19, 2016·Diabetology & Metabolic Syndrome·Maria Candida R ParisiMario José Abdalla Saad
Jun 15, 2017·The New England Journal of Medicine·David G ArmstrongSicco A Bus
May 20, 2018·Diabetes Research and Clinical Practice·María Eugenia López-ValverdeRodrigo Jiménez-García

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Citations

Jun 1, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·R B PaiseyD Walker
Oct 16, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·S SalujaA H Heald
Feb 11, 2020·The International Journal of Lower Extremity Wounds·Gökhun ArıcanKadir Bahadır Alemdaroğlu
Apr 21, 2020·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Clemens HöbausGerit-Holger Schernthaner
Oct 28, 2019·Irish Journal of Medical Science·Hannah FordeDiarmuid Smith
Apr 9, 2020·Archives of Orthopaedic and Trauma Surgery·Madlaina SchöniMartin C Berli
Jun 9, 2020·Diabetic Medicine : a Journal of the British Diabetic Association·R HeggieJ Lewsey
Dec 8, 2020·Journal of Diabetes and Its Complications·Petra JonesDavid Webb
Apr 30, 2021·Journal of Foot and Ankle Research·Benedictine Yen Chen KhorRuth Barn
May 30, 2021·Nature Reviews. Endocrinology·Gordon SloanSolomon Tesfaye
Jun 9, 2021·The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association·Danny R HughesDavid T Mitchell
Aug 10, 2021·Archives of Orthopaedic and Trauma Surgery·Martin C BerliFelix W A Waibel
Dec 22, 2021·Journal of Diabetes Investigation·Ai-Jun JiangQian Li

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Methods Mentioned

BETA
amputations
amputation

Software Mentioned

SAS

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