Amputation of digits or limbs in patients with antiphospholipid syndrome

Seminars in Arthritis and Rheumatism
Ronald A AshersonYehuda Shoenfeld

Abstract

To describe the characteristics of patients with peripheral vascular disease leading to amputation of digits or limbs encountered in patients with the antiphospholipid syndrome (APS). Twenty-one cases derived from several geographical centers (Brazil, Serbia, Italy, Israel, United Kingdom, and South Africa) are presented. The major clinical, serological, and histopathological data (where available) of this cohort are described, documented, and analyzed. Patients were suffering mainly from systemic lupus erythematosus (9 patients) or primary APS (8 patients). Peripheral vascular occlusions occurred during the course of the catastrophic APS in 5 patients. The vascular occlusions occurred both early and very late in the course of the disease (time after APS diagnosis, 0-38 years). Vasculitis was present in 7 patients and 5 demonstrated the typical antiphospholipid antibody (aPL)--vasculopathy with complicating bland thrombosis. Myocardial infarctions had occurred in 4 patients but it was not possible to determine whether they suffered from premature atherosclerotic disease or whether the infarctions were aPL-related. The appearance of livedo reticularis preceding the arterial thrombosis was noted in 9 patients. Cryoglobulinemia wa...Continue Reading

References

Aug 1, 1987·Annals of the Rheumatic Diseases·P DrewG R Hughes
Mar 1, 1988·Clinical Rheumatology·E J Ter BorgC G Kallenberg
Oct 15, 1983·British Medical Journal·G R Hughes
Jun 1, 1995·British Journal of Rheumatology·M A Khamashta, R A Asherson
Apr 18, 1959·Lancet·M H LESSOF, L E GLYNN
Aug 4, 1962·JAMA : the Journal of the American Medical Association·E L DUBOIS, J D ARTERBERRY
Apr 1, 1965·The British Journal of Dermatology·I B SNEDDON
May 1, 1965·Annals of Internal Medicine·D ALARCON SEGOVIA, P J OSMUNDSON

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Citations

Mar 20, 2016·Seminars in Arthritis and Rheumatism·Chrong-Reen Wang, Ming-Fei Liu
Oct 23, 2016·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Kiwako SuzukiShigeru Ichioka
Apr 30, 2013·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Jacob M McLeodPaul A Stone
Jan 16, 2016·Current Rheumatology Reports·P AlbaM C Amigo
Dec 6, 2011·Best Practice & Research. Clinical Rheumatology·Maria J Leandro, Elena Becerra-Fernandez
Aug 22, 2009·British Journal of Haematology·Juan Díaz-CremadesJosé D González-San Miguel
May 28, 2010·Journal of Cutaneous Pathology·Alireza SepehrSteven R Tahan
Sep 28, 2010·The Journal of Hand Surgery·Gregory N Nelson
Sep 19, 2009·Lupus·Gabriela MedinaLuis J Jara
Sep 18, 2015·Vascular and Endovascular Surgery·Nedaa SkeikTimothy Sullivan
Dec 3, 2008·Clinical Reviews in Allergy & Immunology·Ljudmila Stojanovich
Dec 5, 2008·Clinical Reviews in Allergy & Immunology·Ljudmila StojanovichNikola Milinic

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