Amygdala central nucleus function is necessary for learning but not expression of conditioned visual orienting

The European Journal of Neuroscience
Michael McDannaldP C Holland

Abstract

When exposed to pairings of a visual stimulus with food delivery, rats normally acquire both conditioned orienting responses directed toward the visual stimulus and conditioned food-related responses. Consistent with the results of previous lesion studies, reversible inactivation of amygdala central nucleus function before each conditioning session prevented the acquisition of conditioned orienting responses, whereas food-related behaviors were acquired normally. By contrast, neither inactivation nor neurotoxic lesions of central nucleus affected the expression of previously acquired conditioned orienting responses. Thus, the central nucleus is apparently not critical to the maintenance of information required for conditioned orienting, but instead is necessary for memory storage elsewhere. Specialized roles for components of a circuit for conditioned orienting, which includes the central nucleus, the substantia nigra, and dorsolateral striatum, are discussed.

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Citations

Aug 6, 2008·Psychopharmacology·Lee HogarthTheodora Duka
Apr 20, 2010·Psychopharmacology·Gavin D PhillipsPaul K Hitchcott
Jun 12, 2013·Neuropharmacology·Terry E RobinsonBenjamin T Saunders
Apr 21, 2005·Journal of Experimental Psychology. Animal Behavior Processes·Peter C Holland, Cynthia Kenmuir
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Aug 3, 2006·The European Journal of Neuroscience·Heather El-Amamy, Peter C Holland
Apr 23, 2014·The European Journal of Neuroscience·Daniel S WheelerPeter C Holland
Aug 19, 2014·Journal of the Experimental Analysis of Behavior·Megan E OlshavskyHongjoo J Lee
Jun 26, 2015·The European Journal of Neuroscience·Judith S A AsemPeter C Holland
Mar 6, 2012·Brain Research·Stephen E ChangPeter C Holland
Apr 4, 2012·Neurobiology of Learning and Memory·Stephen E ChangPeter C Holland
Aug 27, 2013·Behavioural Processes·Lorenzo Díaz-MataixValérie Doyère
Mar 30, 2018·Nature Reviews. Neuroscience·Joseph LeDoux, Nathaniel D Daw
May 26, 2018·The European Journal of Neuroscience·Rebecca L TomMike J F Robinson
Mar 10, 2018·Current Opinion in Neurobiology·Jonathan P FadokAndreas Lüthi
May 30, 2021·Behavioural Brain Research·Dana M Smith, Mary M Torregrossa

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