Amygdala-Hippocampal Phospholipase D (PLD) Signaling As Novel Mechanism of Cocaine-Environment Maladaptive Conditioned Responses

The International Journal of Neuropsychopharmacology
Balaji Krishnan

Abstract

Drug-environment associative memory mechanisms and the resulting conditioned behaviors are key contributors in relapse to cocaine dependence. Recently, we reported rat amygdala phospholipase D as a key convergent downstream signaling partner in the expression of cocaine-conditioned behaviors mediated by glutamatergic and dopaminergic pathways. In the present study, 1 of the 2 known upstream serotonergic targets of phospholipase D, the serotonin (5-hydroxytryptamine) 2C receptor, was investigated for its role in recruiting phospholipase D signaling in cocaine-conditioned behaviors altered in the rat amygdala and dorsal hippocampus. Using Western-blot analysis, amygdala phospholipase D phosphorylation and total expression of phospholipase D/5-hydroxytryptamine 2C receptor were observed in early (Day-1) and late (Day-14) withdrawal (cocaine-free) states among male Sprague-Dawley rats subjected to 7-day cocaine-conditioned hyperactivity training. Functional studies were conducted using Chinese Hamster Ovary cells with stably transfected human unedited isoform of 5-hydroxytryptamine 2C receptor. Phosphorylation of phospholipase D isoforms was altered in the Day-1 group of cocaine-conditioned animals, while increased amygdala and dec...Continue Reading

References

Jan 1, 1992·Psychopharmacology·R N EhrmanC P O'Brien
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·M T BardoM J Harris
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M K Bennett, R H Scheller
Oct 23, 1997·Neuron·H C BreiterS E Hyman
Jun 3, 1998·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L T Tran-NguyenJ L Neisewander
Jan 9, 1999·Hippocampus·M B Moser, E I Moser
Jan 28, 1999·The Journal of Biological Chemistry·T C SungM A Frohman
Apr 25, 2000·Neuron·J D Berke, S E Hyman
Sep 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·N BurgessJ O'Keefe
Nov 15, 2001·Cellular and Molecular Life Sciences : CMLS·S Cockcroft
Dec 26, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HumeauB Poulain
Mar 13, 2002·Pharmacology, Biochemistry, and Behavior·Daniel HoyerGraeme R Martin
Oct 29, 2002·FEBS Letters·John H Exton
Nov 15, 2002·The Journal of Biological Chemistry·Tianhui Hu, John H Exton
Jul 23, 2003·Pharmacology, Biochemistry, and Behavior·Christian BrabantEzio Tirelli
Jan 14, 2004·Molecular Biology of the Cell·Guangwei DuMichael A Frohman
Apr 17, 2004·The Journal of Biological Chemistry·William E HughesTrevor J Biden
Jul 1, 2004·Neuroscience and Biobehavioral Reviews·D M BannermanJ Feldon
Jul 30, 2004·Molecular and Cellular Biology·Wahn Soo ChoiMichael A Beaven
Jan 18, 2005·Biochemical and Biophysical Research Communications·Tianhui Hu, John H Exton
Aug 2, 2005·The American Journal of Psychiatry·Steven E Hyman
Jun 17, 2006·Annual Review of Neuroscience·Steven E HymanEric J Nestler
Oct 20, 2006·Pharmacology & Therapeutics·K D Alex, E A Pehek
Sep 1, 2007·Behavioural Pharmacology·Elif Engin, Dallas Treit
Jun 24, 2008·Pharmacology, Biochemistry, and Behavior·Robert J CareyArielle B Shanahan
Jul 22, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Hans S CrombagYavin Shaham
Aug 5, 2008·Trends in Pharmacological Sciences·Mark J MillanClotilde Mannoury la Cour

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Citations

Mar 22, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Balaji KrishnanGiulio Taglialatela

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Methods Mentioned

BETA
Immunoprecipitation
Infrared Imaging
coimmunoprecipitation
pulldowns

Software Mentioned

Odyssey Infrared Imaging System Application
GraphPad InStat
GraphPad

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