Amygdala hyper-connectivity in a mouse model of unpredictable early life stress

Translational Psychiatry
Frances K JohnsonArie Kaffman

Abstract

Childhood maltreatment is associated with a wide range of psychopathologies including anxiety that emerge in childhood and in many cases persist in adulthood. Increased amygdala activation in response to threat and abnormal amygdala connectivity with frontolimbic brain regions, such as the hippocampus and the prefrontal cortex, are some of the most consistent findings seen in individuals exposed to childhood maltreatment. The underlying mechanisms responsible for these changes are difficult to study in humans but can be elucidated using animal models of early-life stress. Such studies are especially powerful in the mouse where precise control of the genetic background and the stress paradigm can be coupled with resting-state fMRI (rsfMRI) to map abnormal connectivity in circuits that regulate anxiety. To address this issue we first compared the effects of two models of early-life stress, limited bedding (LB) and unpredictable postnatal stress (UPS), on anxiety-like behavior in juvenile and adult mice. We found that UPS, but not LB, causes a robust increase in anxiety in juvenile and adult male mice. Next, we used rsfMRI to compare frontolimbic connectivity in control and UPS adult male mice. We found increased amygdala-prefront...Continue Reading

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Citations

Oct 4, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Maarten NaeyaertMarleen Verhoye
Apr 16, 2019·The British Journal of Radiology·Sue Y YiJohn-Paul J Yu
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Oct 27, 2020·Frontiers in Neuroscience·Hanista PremachandranMaithe Arruda-Carvalho
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Mar 5, 2021·Behavioural Pharmacology·Sarah J Cross, Frances M Leslie
May 19, 2021·Neuroscience and Biobehavioral Reviews·Martina MannsSebastian Ocklenburg
Aug 24, 2021·Developmental Psychobiology·Malaz KreikerKevin L Brown

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Methods Mentioned

BETA
dissections
sedation

Software Mentioned

EthoVision
imageJ
rsFMRI
SPSS Statistics
SPM12
Stereo Investigator
MATLAB

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