Amygdala input monosynaptically innervates parvalbumin immunoreactive local circuit neurons in rat medial prefrontal cortex

Neuroscience
Paul GabbottSarah Busby

Abstract

The projection from the basolateral nucleus of the amygdala (BLA) conveys information about the affective significance of sensory stimuli to the medial prefrontal cortex (mPFC). By using an anterograde tract-tracing procedure combined with immunocytochemistry and correlated light/electron microscopical examination, labeled BLA afferents to layers 2-6 of the rat mPFC are shown to establish asymmetrical synaptic contacts, not only with dendritic spines (approximately 95.7% of targets innervated), but also with the aspiny dendritic shafts and somata of multipolar parvalbumin immunopositive (PV+) neurons. A population of PV- dendritic shafts was also innervated. Labeled BLA synaptic input to identified PV+ structures occurred in layers 2-6 of mPFC. The results indicate that labeled BLA afferents predominantly contact the spiny processes of presumed pyramidal cells and also provide a direct and specific innervation to a sub-population of local circuit neurons in mPFC containing PV. Since PV+ cells include two significant classes of fast-spiking GABAergic inhibitory interneuron (basket and axo-axonic cells), these novel observations indicate that the amygdalocortical pathway in the rat has the ability to directly influence functional...Continue Reading

References

Jan 15, 1977·The Journal of Comparative Neurology·J E Krettek, J L Price
Aug 1, 1990·The Journal of Comparative Neurology·H Kita, S T Kitai
Jan 8, 1989·The Journal of Comparative Neurology·M D CassellD J Wright
Feb 20, 1995·The Journal of Comparative Neurology·F CondéF Crépel
May 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J DeFelipe, A Fairén
Sep 1, 1997·Cerebral Cortex·Y Kawaguchi, Y Kubota
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Aug 9, 2001·The Journal of Comparative Neurology·P BuzásZ F Kisvárday
Nov 8, 2002·Nature·Mohammed R Milad, Gregory J Quirk
Sep 3, 2003·Acta Psychiatrica Scandinavica. Supplementum·D S Charney
Dec 4, 2003·Behavioural Brain Research·Harry B M UylingsBryan Kolb
Dec 19, 2003·Neuropharmacology·Ciara McCabeJulian C Leslie
Feb 13, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benno RoozendaalJames L McGaugh
Jun 4, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yinghua ZhuJ Julius Zhu
Jun 24, 2004·Journal of Neurophysiology·Denis ParéJoseph E Ledoux
Jul 6, 2004·The European Journal of Neuroscience·Patrick L TierneyYves Gioanni
Jan 1, 2005·Toxicology Mechanisms and Methods·Kamil Kuca, Jirí Cabal

❮ Previous
Next ❯

Citations

Aug 25, 2007·Brain Structure & Function·Walter B Hoover, Robert P Vertes
Jun 4, 2011·Brain Structure & Function·Heinz Künzle
Jun 3, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Vladimir I CheferToni S Shippenberg
Mar 9, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Behnaz Esmaeili, Anthony A Grace
Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chi-Hua ChenEd Bullmore
Sep 2, 2011·Journal of Neurophysiology·Guangchen Ji, Volker Neugebauer
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guangchen JiVolker Neugebauer
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anthony Burgos-RoblesGregory J Quirk
Jun 16, 2014·Trends in Neurosciences·Marieke R GilmartinFred J Helmstetter
Dec 8, 2015·Cerebral Cortex·Ramon GuiradoEero Castrén
Jul 12, 2011·Brain Research·Mototaka Nakama-Kitamura, Yoshihisa Kitamura
Jan 24, 2009·Brain Research Reviews·Volker NeugebauerSean C Mackey
Nov 24, 2007·Behavioural Brain Research·Hisao NishijoTaketoshi Ono
Oct 13, 2007·Neuroscience·M M Morshedi, Gloria E Meredith
Dec 1, 2015·Frontiers in Behavioral Neuroscience·Thomas F Giustino, Stephen Maren
Jun 16, 2007·Neurobiology of Aging·Marisa J RubinowJanice M Juraska
Mar 14, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Susanne BrummelteGertraud Teuchert-Noodt
Mar 4, 2008·The Journal of Comparative Neurology·Robert P Vertes, Walter B Hoover
Jan 17, 2012·The Journal of Comparative Neurology·Paul GabbottSarah Busby
Mar 1, 2016·Neurobiology of Disease·Elizabeth G PittsShannon L Gourley
Aug 8, 2015·Brain Structure & Function·Yvonne M Ulrich-LaiJames P Herman
Mar 12, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rong-Jian LiuGeorge K Aghajanian
Nov 28, 2012·Neuron·Francisco Sotres-BayonGregory J Quirk
Mar 19, 2013·Neuroscience·J CourtinC Herry
Sep 25, 2009·The International Journal of Neuropsychopharmacology·Hui-Ching LinPo-Wu Gean
Dec 3, 2014·Frontiers in Pharmacology·Lauren M DePoyShannon L Gourley
Oct 22, 2016·Neuroscience and Biobehavioral Reviews·Adriana CaballeroKuei Y Tseng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.