Jun 9, 2014

Amygdala microcircuits controlling learned fear

Neuron
Sevil Duvarci, D Paré

Abstract

We review recent work on the role of intrinsic amygdala networks in the regulation of classically conditioned defensive behaviors, commonly known as conditioned fear. These new developments highlight how conditioned fear depends on far more complex networks than initially envisioned. Indeed, multiple parallel inhibitory and excitatory circuits are differentially recruited during the expression versus extinction of conditioned fear. Moreover, shifts between expression and extinction circuits involve coordinated interactions with different regions of the medial prefrontal cortex. However, key areas of uncertainty remain, particularly with respect to the connectivity of the different cell types. Filling these gaps in our knowledge is important because much evidence indicates that human anxiety disorders results from an abnormal regulation of the networks supporting fear learning.

Mentioned in this Paper

Biochemical Pathway
Cyclic AMP-Responsive DNA-Binding Protein
Presynaptic Terminals
EGR1 gene
Exertion
Cortex Bone Disorders
Adrenal Cortex Diseases
Entire Brainstem
Neostriatum
Projections and Predictions

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