Amygdala-prefrontal cortex white matter tracts are widespread, variable and implicated in amygdala modulation in adolescents

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Leigh G GoetschiusChristopher S Monk

Abstract

The amygdala is critically involved in processing emotion. Through bidirectional connections, the prefrontal cortex (PFC) is hypothesized to influence amygdala reactivity. However, research that elucidates the nature of amygdala-PFC interactions - through mapping amygdala-prefrontal tracts, quantifying variability among tracts, and linking this variability to amygdala activation - is lacking. Using probabilistic tractography to map amygdala-prefrontal white matter connectivity in 142 adolescents, the present study found that white matter connectivity was greater between the amygdala and the subgenual cingulate, orbitofrontal (OFC), and dorsomedial (dmPFC) prefrontal regions than with the dorsal cingulate and dorsolateral regions. Then, using a machine-learning regression, we found that greater amygdala-PFC white matter connectivity was related to attenuated amygdala reactivity. This effect was driven by amygdala white matter connectivity with the dmPFC and OFC, supporting implicit emotion processing theories which highlight the critical role of these regions in amygdala regulation. This study is among the first to map and compare specific amygdala-prefrontal white matter tracts and to relate variability in connectivity to amygd...Continue Reading

Citations

Jul 12, 2019·Frontiers in Behavioral Neuroscience·Anouchka JunodRegina M Sullivan
Apr 8, 2020·Journal of Psychiatry and Brain Science·Julie E PremoKate D Fitzgerald
Oct 27, 2020·Social Cognitive and Affective Neuroscience·Tyler C HeinChristopher S Monk
Oct 23, 2019·Psychoneuroendocrinology·Melissa K PeckinsNestor L Lopez-Duran
Jan 26, 2021·Development and Psychopathology·Arianna M GardLuke W Hyde
Sep 6, 2020·Developmental Cognitive Neuroscience·Leigh G GoetschiusChristopher S Monk
Aug 10, 2021·Clinical Psychological Science : a Journal of the Association for Psychological Science·Hailey L DottererLuke W Hyde
Nov 21, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yael S GrossmanDani Dumitriu

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