Amygdala Reward Reactivity Mediates the Association Between Preschool Stress Response and Depression Severity

Biological Psychiatry
Michael GaffreyJoan Luby

Abstract

Research in adolescents and adults has suggested that altered neural processing of reward following early life adversity is a highly promising depressive intermediate phenotype. However, very little is known about how stress response, neural processing of reward, and depression are related in very young children. The present study examined the concurrent associations between cortisol response following a stressor, functional brain activity to reward, and depression severity in children 4 to 6 years old. Medication-naïve children 4 to 6 years old (N = 52) participated in a study using functional magnetic resonance imaging to assess neural reactivity to reward, including gain, loss, and neutral outcomes. Parent-reported child depression severity and child cortisol response following stress were also measured. Greater caudate and medial prefrontal cortex reactivity to gain outcomes and increased amygdala reactivity to salient (i.e., both gain and loss) outcomes were observed. Higher total cortisol output following a stressor was associated with increased depression severity and reduced amygdala reactivity to salient outcomes. Amygdala reactivity was also inversely associated with depression severity and was found to mediate the re...Continue Reading

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Citations

Nov 22, 2019·Current Psychiatry Reports·Meghan Rose DonohueJoan Luby
Jun 24, 2020·Psychopharmacology·Suwarna ChakrabortyB S Shankaranarayana Rao
Jan 20, 2021·Pediatric Research·Marcela LopezKanwaljeet J S Anand
Jan 7, 2021·Research on Child and Adolescent Psychopathology·Jamilah SilverDaniel N Klein
May 10, 2019·Psychiatry Research. Neuroimaging·Deanna M BarchJoan L Luby
Apr 10, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·A O Kibitov, G E Mazo
May 18, 2021·Neurobiology of Stress·Carina H FowlerMichael S Gaffrey
Jun 20, 2021·Journal of the American Academy of Child and Adolescent Psychiatry·Dongtao WeiAnqi Qiu
Oct 15, 2021·The American Journal of Psychiatry·Jennifer S StevensKerry J Ressler
Sep 4, 2019·Developmental Neuroscience·Kathryn M BroadhouseDaniel F Hermens

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