Feb 12, 2017

Amygdalar Gating of Early Sensory Processing through Interactions with Locus Coeruleus

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Cynthia D Fast, John P McGann

Abstract

Fear- and stress-induced activity in the amygdala has been hypothesized to influence sensory brain regions through the influence of the amygdala on neuromodulatory centers. To directly examine this relationship, we used optical imaging to observe odor-evoked activity in populations of olfactory bulb inhibitory interneurons and of synaptic terminals of olfactory sensory neurons (the primary sensory neurons of the olfactory system, which provide the initial olfactory input to the brain) during pharmacological inactivation of amygdala and locus coeruleus (LC) in mice. Although the amygdala does not directly project to the olfactory bulb, joint pharmacological inactivation of the central, basolateral, and lateral nuclei of the amygdala nonetheless strongly suppressed odor-evoked activity in GABAergic inhibitory interneuron populations in the OB. This suppression was prevented by inactivation of LC or pretreatment of the olfactory bulb with a broad-spectrum noradrenergic receptor antagonist. Visualization of synaptic output from olfactory sensory neuron terminals into the olfactory bulb of the brain revealed that amygdalar inactivation preferentially strengthened the odor-evoked synaptic output of weakly activated populations of sen...Continue Reading

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Mentioned in this Paper

Health Center
Study
Central
Presynaptic Terminals
Inhibitory Interneuron
Structure of Olfactory Bulb
Antagonist Muscle Action
Brain
Spinal Ataxia
Adenosine receptor antagonist

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