Abstract
Information about the natural compound amygdalin, which is employed as an antitumor agent, is sparse and thus its efficacy remains controversial. In this study, to determine whether amygdalin exerts antitumor effects on renal cell carcinoma (RCC) cells, its impact on RCC metastatic activity was investigated. The RCC cell lines, Caki-1, KTC-26 and A498, were exposed to amygdalin from apricot kernels, and adhesion to human vascular endothelium, immobilized collagen or fibronectin was investigated. The influence of amygdalin on chemotactic and invasive activity was also determined, as was the influence of amygdalin on surface and total cellular α and β integrin expression, which are involved in metastasis. We noted that amygdalin caused significant reductions in chemotactic activity, invasion and adhesion to endothelium, collagen and fibronectin. Using FACScan analysis, we noted that amygdalin also induced reductions, particularly in integrins α5 and α6, in all three cell lines. Functional blocking of α5 resulted in significantly diminished adhesion of KTC-26 and A498 to collagen and also in decreased chemotactic behavior in all three cell lines. Blocking α6 integrin significantly reduced chemotactic activity in all three cell lin...Continue Reading
References
Jan 28, 1982·The New England Journal of Medicine·C G MoertelJ P Davignon
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·M M ZutterY L Tsung
Sep 21, 2006·Molecular Cancer Therapeutics·Parisa KhaliliShafaat A Rabbani
May 8, 2007·Cancer Research·Yorihisha ImanishiShi-Yuan Cheng
May 14, 2008·Neoplasia : an International Journal for Oncology Research·Zobeida Cruz-Monserrate, Kathleen L O'Connor
Oct 8, 2009·Molecular Cancer Research : MCR·Tae Hyong KimJun Chung
Mar 4, 2010·Cancer Research·Xiuwei H YangMartin E Hemler
Dec 2, 2010·Oncogene·A K MitraE Lengyel
May 25, 2011·Mutation Research·Franziska van ZijlWolfgang Mikulits
Jul 12, 2012·British Journal of Cancer·I TsaurR A Blaheta
Nov 10, 2012·The Journal of Biological Chemistry·Cristina TringaliBruno Venerando
Dec 6, 2012·Oncotarget·Sora LeeDai H Chung
Jul 31, 2013·Surgery·Sora LeeDai H Chung
Oct 1, 2013·Oncogene·S CagnetM A Glukhova
Oct 12, 2013·The Prostate·Estelle RicciMarc Colombel
Feb 6, 2014·British Journal of Cancer·N M A WhiteG M Yousef
May 28, 2014·Neoplasia : an International Journal for Oncology Research·Eva JuengelRoman A Blaheta
Jun 3, 2014·Molecular Cancer·Elizabeth SalvoAna Rouzaut
Jul 11, 2014·Anti-cancer Drugs·Cui-Cui SunZu-Hua Gao
Aug 20, 2014·PloS One·Jasmina MakarevićRoman A Blaheta
Sep 3, 2014·World Journal of Urology·Igor TsaurRoman A Blaheta
Oct 22, 2014·PloS One·Jasmina MakarevićRoman A Blaheta
Citations
Jan 6, 2018·International Journal of Molecular Sciences·Inamul HaqueSushanta K Banerjee
Jul 13, 2019·Nutrition and Cancer·Jens ManiRoman A Blaheta
Nov 6, 2018·International Journal of Oncology·Masayoshi YamaguchiTomiyasu Murata
Jan 29, 2021·Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes·Radoslav OmelkaMonika Martiniakova
Mar 19, 2021·Journal of Medicinal Food·Davut AydınAli Aydın
Jun 9, 2020·Anti-cancer Agents in Medicinal Chemistry·Samar HosnyAmr Negm