Amygdaloid kindling by repeated focal N-methyl-D-aspartate administration: comparison with electrical kindling

European Journal of Pharmacology
M J CroucherH F Bradford

Abstract

Limbic seizures were kindled by repeated, daily intra-amygdaloid microinjections of N-methyl-D-aspartate (NMDA; 2 nmol). The seizures, and accompanying afterdischarges, closely resembled those seen following electrical kindling of the amygdala. As with electrical kindling, co-administration of the competitive NMDA receptor antagonist DL-2-amino-7-phosphonoheptanoic acid (AP7; 70 nmol) prevented the development of seizure activity. NMDA-induced kindling was durable, lasting at least 1 month, and showed positive transfer to electrical kindling. Fully kindled seizures were inhibited by co-administration of the potent NMDA receptor antagonist DL-[E]-2-amino-4-methyl-5-phosphono-3-pentenoic acid (CGP 37849) with the agonist. These results strongly support a role for NMDA receptors in kindling epileptogenesis.

References

Jul 30, 1976·Brain Research·P R Dodd, H F Bradford
May 1, 1976·Journal of Neurochemistry·L P Davies, G A Johnston
Feb 1, 1991·Brain Research. Molecular Brain Research·J L SonnenbergS Christakos
Jan 8, 1990·Brain Research·M J Croucher, H F Bradford
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G C YehJ O McNamara
Oct 1, 1989·Experimental Neurology·S M Jones, K M Johnson
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Mar 1, 1981·Journal of Neurochemistry·J H Skerritt, G A Johnston

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Citations

Dec 1, 1995·Progress in Neurobiology·H F Bradford
Jan 29, 1997·European Journal of Pharmacology·M J CroucherH F Bradford
Jun 5, 1999·European Journal of Pharmacology·D L YourickJ L Meyerhoff
Oct 9, 1999·Epilepsy Research·B S MeldrumA G Chapman
Oct 4, 2008·Cerebral Cortex·Li-Feng QiuZhi-Qi Xiong
Jun 15, 2004·Progress in Neurobiology·Kiyoshi MorimotoRonald J Racine
Apr 29, 2005·Neuropharmacology·Jesper F BastlundWilliam P Watson
Mar 2, 2005·Pharmacology & Therapeutics·Robert J DelorenzoLaxmikant S Deshpande
Dec 21, 2006·Neuroscience and Behavioral Physiology·N Ya LukomskayaL G Magazanik

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