PMID: 6170423Dec 1, 1981Paper

Amylase-producing lung cancer: case report and review of the literature

Cancer
S KatayamaT Nakayama

Abstract

A case of hyperamylasemia with lung cancer is described. Macroamylasemia was excluded by a normal amylase/creatinine clearance ratio and by a sedimentation constant obtained by sucrose density gradient centrifugation. Positive immunofluorescent staining of tumor cells with a specific antibody against human salivary amylase and significant amylase activity in the primary tumor and metastases support the hypothesis of independent production of amylase by the lung tumor. Cellulose--acetate membrane electrophoresis demonstrated three bands of amylase activity. The major component corresponded to normal salivary amylase in electrophoretic mobility, isoelectric point and molecular size. The minor bands, one of which occupied about 10% of the total amylase activity in serum, urine and tissue homogenates, demonstrated a lower electrophoretic mobility and a more acidic isoelectric point. Gel filtration and electrophoresis disclosed that these minor bands were derived from an amylase isozyme with a larger molecular size than that of normal salivary amylase. The results suggest ectopic tumor production of heterogenous amylase isozymes, with the larger form being secreted into the circulation.

References

Feb 23, 1975·The New England Journal of Medicine·A L Warshaw, A F Fuller
Jul 31, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·T TakeuchiT Takeuchi
Oct 2, 1969·The New England Journal of Medicine·L L StolbachW H Fishman
Apr 1, 1973·Annals of Internal Medicine·R W AmmannW Wegmann
Apr 1, 1970·Archives of Biochemistry and Biophysics·D L KauffmanP J Keller
Dec 1, 1969·Clinica Chimica Acta; International Journal of Clinical Chemistry·M CeskaK Birath
May 1, 1957·Cancer·R L McGEACHIN, M R ADAMS
Nov 1, 1951·American Journal of Clinical Pathology·M J WEISSM WERTMAN

❮ Previous
Next ❯

Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y YoshidaA Suzuki
Nov 24, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·A N Savel'evK N Neustroev
Jun 1, 1983·The Journal of Surgical Research·D W ClinkD W Weaver
Jan 1, 1985·Critical Reviews in Clinical Laboratory Sciences·J J Zakowski, D E Bruns
May 31, 2016·Turkish Journal of Emergency Medicine·Sinan BecelGul Pamukcu Gunaydin
Aug 26, 1998·Liver·M GalusD Olkowska
Apr 25, 2006·Gastroentérologie Clinique Et Biologique·Philippe Lévy

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.