PMID: 6161471Jan 1, 1980Paper

Amylase producing lung cancer. Electronmicroscopical and biochemical studies

Virchows Archiv. A, Pathological Anatomy and Histology
T MorohoshiM Kanda

Abstract

A case of the lung cancer associated with marked elevation of serum (7820 IU/1) and of urinary amylase (2225 IU/1) was autopsied. Material was examined histopathologically, electronmicroscopically and biochemically. The pulmonary tumor tissues showed histological pattern of papillary adenocarcinoma. In addition to the small round bodies which were very similar to secretory granules, many large round bodies were noticed, diffusely distributed in the tumor cell. These large round bodies ranged from 0.2 to 0.7 micrometers in diameter and showed a lamellar or annular pattern. The soluble phase of the homogenized pulmonary tumor tissues had an amylase level of 11,300 IU/g of protein, which consisted of S-type isoamylase with minor components. Cholesterol, triglyceride and phospholipid were also present at greater concentration in the tumor tissue than the normal pulmonary tissue. The large round bodies appeared too, to be amylase including bodies from the electronmicroscopical and biochemical findings.

References

Apr 1, 1977·Cancer·M OtsukiT Yamasaki
Nov 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·K Sudo, T Kanno
Apr 1, 1973·Annals of Internal Medicine·R W AmmannW Wegmann
Nov 1, 1951·American Journal of Clinical Pathology·M J WEISSM WERTMAN

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Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·Y YoshidaA Suzuki
Aug 1, 1989·Blood·H Matsuzaki, K Takatsuki
Feb 26, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Takanori Moriyama
Sep 1, 1982·Journal of Surgical Oncology·P C Martin, D P Sarma
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·M TakeyaK Takahashi

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