Amylin as a potential link between type 2 diabetes and alzheimer disease

Annals of Neurology
Ivan Martinez-ValbuenaMaria-Rosario Luquin

Abstract

Alzheimer disease (AD) is the leading cause of dementia, and although its etiology remains unclear, it seems that type 2 diabetes mellitus (T2DM) and other prediabetic states of insulin resistance could contribute to the appearance of sporadic AD. As such, we have assessed whether tau and β-amyloid (Aβ) deposits might be present in pancreatic tissue of subjects with AD, and whether amylin, an amyloidogenic protein deposited in the pancreas of T2DM patients, might accumulate in the brain of AD patients. We studied pancreatic and brain tissue from 48 individuals with no neuropathological alterations and from 87 subjects diagnosed with AD. We examined Aβ and tau accumulation in the pancreas as well as that of amylin in the brain. Moreover, we performed proximity ligation assays to ascertain whether tau and/or Aβ interact with amylin in either the pancreas or brain of these subjects. Cytoplasmic tau and Aβ protein deposits were detected in pancreatic β cells of subjects with AD as well as in subjects with a normal neuropathological examination but with a history of T2DM and in a small cohort of control subjects without T2DM. Furthermore, we found amylin deposits in the brain of these subjects, providing histological evidence that a...Continue Reading

References

Dec 22, 1999·Neurology·A OttM M Breteler
Dec 20, 2005·Lancet Neurology·Geert Jan BiesselsPhilip Scheltens
Apr 11, 2007·Archives of Neurology·José A LuchsingerRichard Mayeux
May 15, 2007·Kidney International·W GongL S Li
Jul 16, 2008·Methods : a Companion to Methods in Enzymology·Ola SöderbergUlf Landegren
Oct 28, 2008·Neurobiology of Aging·Judith MiklossyPatrick L McGeer
Jan 3, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Alex E RoherMarwan N Sabbagh
Jan 24, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bradley T HymanThomas J Montine
Jun 25, 2013·Annals of Neurology·Kaleena JacksonFlorin Despa
Sep 7, 2013·ACS Chemical Neuroscience·Workalemahu M BerhanuUlrich H E Hansmann
Jan 21, 2014·Biochimica Et Biophysica Acta·Kenjiro OnoMasahito Yamada
May 21, 2014·Journal of Diabetes Investigation·Kapil GudalaAnil Bhansali
Aug 26, 2014·Molecular Neurodegeneration·Sarah SrodulskiFlorin Despa
Nov 12, 2014·Current Alzheimer Research·Janelle N FawverIan V J Murray
Feb 24, 2015·The American Journal of Pathology·Marie E OskarssonGunilla T Westermark
Mar 4, 2015·Brain : a Journal of Neurology·Rosalind F RobertsJavier Alegre-Abarrategui
Jul 3, 2015·Frontiers in Neuroscience·Thomas A Lutz, Urs Meyer
Jan 30, 2016·Journal of Diabetes Research·Magdalena MajJohannes Attems
Jan 1, 2015·Nature Reviews. Disease Primers·Colin L MastersJeffrey L Cummings
Apr 8, 2017·Acta Neuropathologica·Tong GuoDiane P Hanger
Jul 25, 2017·Lancet·Gill LivingstonNaaheed Mukadam
Nov 17, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark A J GorrisCarl G Figdor
Nov 25, 2017·Neuropharmacology·Nadeeja WijesekaraPaul E Fraser
Jan 30, 2018·Nature Reviews. Neurology·Steven E ArnoldDavid M Nathan
Feb 7, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nadeeja WijesekaraPaul E Fraser
Mar 15, 2018·Acta Neuropathologica·Ivan Martinez-ValbuenaMaria-Rosario Luquin
Jun 14, 2018·Nature Reviews. Neurology·Erin E Congdon, Einar M Sigurdsson
Jul 20, 2018·Nature Reviews. Endocrinology·Geert Jan Biessels, Florin Despa

❮ Previous
Next ❯

Citations

Jan 10, 2020·Annals of Neurology·Florin DespaGeert Jan Biessels
Feb 12, 2020·International Journal of Environmental Research and Public Health·Md Habibur RahmanMohammad Ali Moni
Oct 2, 2020·Advanced Science·Ibrahim JavedPu Chun Ke
Mar 27, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zhitong ZhengJieli Chen
Sep 3, 2020·Journal of Clinical Medicine·Aleksandra GaseckaCeren Eyileten
Jun 28, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marta Abengozar-MuelaCarlos E de Andrea
Sep 11, 2020·Journal of Neurochemistry·Jessica Diniz PereiraKarina Braga Gomes
Dec 1, 2020·Biophysical Chemistry·Magdalena I IvanovaAyyalusamy Ramamoorthy
Nov 6, 2020·International Journal of Molecular Sciences·Joanne Elizabeth RowlesPhilip Newsholme
Feb 2, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Han LyFlorin Despa
Nov 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sherin AbdelrahmanMariusz Jaremko
Oct 11, 2020·Parkinsonism & Related Disorders·Anna DelamarreWassilios G Meissner
Mar 7, 2021·Chemistry and Physics of Lipids·Sara García-ViñualesDanilo Milardi
Dec 31, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marc Garcia-MoureMarta M Alonso
Feb 3, 2021·European Journal of Clinical Investigation·Thamonwan DiteepengMarco Luciani
Mar 22, 2021·Fluids and Barriers of the CNS·Francesco GirolamoDaniela Virgintino
Apr 10, 2021·Acta Neuropathologica Communications·Ivan Martinez-ValbuenaMaría-Rosario Luquin
Feb 11, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tayla A ReesChristopher S Walker
May 6, 2021·Stroke; a Journal of Cerebral Circulation·Florin Despa, Larry B Goldstein
Jun 3, 2021·Cells·Jesús BurilloCarlos Guillén
Jun 12, 2021·Ageing Research Reviews·Masayoshi TasakiMitsuharu Ueda
Oct 13, 2019·Current Medicinal Chemistry·Agnieszka JankowskaGrażyna Chłoń-Rzepa
Aug 3, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Gilda E EnnisBarbara B Bendlin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.