Amylin-induced relaxation of the perfused mesenteric arterial bed: meditation by calcitonin gene-related peptide receptors

Journal of Cardiovascular Pharmacology
T C Westfall, M Curfman-Falvey

Abstract

Amylin is a 37-amino acid peptide that shares considerable homology with calcitonin gene-related peptide (CGRP). Both peptides exert glycoregulatory actions and produce vasodilation of the cardiovascular system. We wished to determine if amylin exerts vasodilatory action in the perfused mesenteric arterial bed in a manner similar to that of CGRP and if so, to determine if amylin and CGRP share a common mechanism of action. Amylin 10(-8), 10(-7), and 10(-6)M produced significant decreases in perfusion pressure by 18, 34, and 45 mm Hg, respectively, of the perfused mesenteric arterial bed pretreated with guanethidine (7 x 10(-6)M) and precontracted with methoxamine (10(-6)-10(-5)M). Amylin was approximately 10 times less potent than CGRP. This vasodilatory effect was not antagonized by atropine in a concentration (10(-6)M) that blocked the vasodilatory action of acetylcholine (ACh) or of nadolol in a concentration that blocked the response to isoproterenol (ISO 10(-6)M). In contrast, the CGRP receptor antagonist [8-37]hCGRP blocked the response of both amylin and CGRP while failing to block the effect of ISO. The depressor effects of CGRP (10(-8)M), amylin (10(-6)M), and ISO (10(-5)M) were 38, 43, and 42 mm Hg without and 5, 12, ...Continue Reading

Citations

Jun 5, 2004·Pathophysiology : the Official Journal of the International Society for Pathophysiology·G.E. SamoninaA.A. Guseva
Jun 14, 2000·European Journal of Pharmacology·O Saetrum OpgaardL Edvinsson
Mar 10, 2001·European Journal of Pharmacology·I Jansen-OlesenL Edvinsson
Dec 23, 1999·European Journal of Pharmacology·O Saetrum OpgaardP R Saxena
Aug 7, 2002·British Journal of Pharmacology·Katherine E Wiley, Anthony P Davenport
May 20, 2000·Annals of the New York Academy of Sciences·Z SuoM Mullan
Jul 3, 2015·Frontiers in Neuroscience·Thomas A Lutz, Urs Meyer
Aug 15, 2014·Frontiers in Aging Neuroscience·Wei Qiao Qiu, Haihao Zhu
Apr 2, 2017·Neuropharmacology·Haihao ZhuWei Qiao Qiu
May 16, 2017·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Haihao ZhuWei Qiao Qiu
Sep 16, 1999·FEBS Letters·Y WangG J Cooper

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.