Amylin Selectively Signals Onto POMC Neurons in the Arcuate Nucleus of the Hypothalamus

Diabetes
Thomas A LutzChristelle Le Foll

Abstract

Amylin phosphorylates ERK (p-ERK) in the area postrema to reduce eating and synergizes with leptin to phosphorylate STAT3 in the arcuate (ARC) and ventromedial (VMN) hypothalamic nuclei to reduce food intake and body weight. The current studies assessed potential amylin and amylin-leptin ARC/VMN interactions on ERK signaling and their roles in postnatal hypothalamic pathway development. In amylin knockout mice, the density of agouti-related protein (AgRP)-immunoreactive (IR) fibers in the hypothalamic paraventricular nucleus (PVN) was increased, while the density of α-melanocyte-stimulating hormone (αMSH) fibers was decreased. In mice deficient of the amylin receptor components RAMP1/3, both AgRP and αMSH-IR fiber densities were decreased, while only αMSH-IR fiber density was decreased in rats injected neonatally in the ARC/VMN with an adeno-associated virus short hairpin RNA against the amylin core receptor. Amylin induced p-ERK in ARC neurons, 60% of which was present in POMC-expressing neurons, with none in NPY neurons. An amylin-leptin interaction was shown by an additive effect on ARC ERK signaling in neonatal rats and a 44% decrease in amylin-induced p-ERK in the ARC of leptin receptor-deficient and of ob/ob mice. Togethe...Continue Reading

References

Mar 1, 1990·The Journal of Clinical Investigation·A OgawaK L Luskey
Dec 1, 1972·Developmental Biology·W R Clark, W J Rutter
Mar 10, 2001·Nature·L Chang, M Karin
Jul 10, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T A LutzE Scharrer
Nov 14, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T RiedigerE Simon
Dec 7, 2002·Behavior Genetics·Alexander A BachmanovMichael G Tordoff
Feb 1, 2003·Neuroscience·K L GroveM S Smith
Jun 24, 2003·Physiology & Behavior·Kevin L Grove, M Susan Smith
Sep 6, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T RiedigerT A Lutz
Mar 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sebastien G BouretRichard B Simerly
Mar 27, 2004·Endocrinology·Sebastien G Bouret, Richard B Simerly
Apr 6, 2004·Science·Sebastien G BouretRichard B Simerly
Jan 6, 2005·Journal of Biochemistry·Satoru ToriiEisuke Nishida
Aug 2, 2006·EMBO Reports·Satoko Nishimoto, Eisuke Nishida
Dec 21, 2006·American Journal of Physiology. Endocrinology and Metabolism·Christelle Le FollJacques Delarue
Feb 6, 2008·Cell Metabolism·Sebastien G BouretRichard B Simerly
May 7, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jonathan D RothAlain D Baron
Jan 23, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christa M PattersonBarry E Levin
Oct 31, 2009·Endocrinology·Victoria F TurekJonathan D Roth
Apr 13, 2010·Brain Research·Catarina Soares PotesThomas Riediger
Jun 18, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catarina S PotesThomas A Lutz
Dec 2, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Catarina Soares PotesThomas Alexander Lutz
Jan 18, 2012·Handbook of Experimental Pharmacology·Thomas Alexander Lutz
Jan 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sebastien G BouretRichard B Simerly
Feb 14, 2012·The Journal of Clinical Investigation·Eric D BerglundJoel K Elmquist
May 25, 2012·Endocrinology·Yuko Ishii, Sebastien G Bouret
Feb 27, 2013·Frontiers in Neuroscience·Aaron J MercerMalcolm J Low
Jul 22, 2014·The European Journal of Neuroscience·Fiona E BraeggerChristina N Boyle
Dec 6, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christelle Le FollBarry E Levin
Jun 14, 2015·Pharmacological Reviews·Debbie L HayJonathan D Roth
Dec 18, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ambrose A Dunn-MeynellBarry E Levin
May 12, 2016·Cell Metabolism·Zhiying LiJeffrey Michael Friedman
Aug 19, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Louise LarsenBarry E Levin
Sep 16, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Miranda D JohnsonBarry E Levin
Dec 13, 2016·Trends in Endocrinology and Metabolism : TEM·Barry E Levin, Thomas A Lutz

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Citations

Aug 23, 2018·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sonya DuffyChristina N Boyle
Mar 10, 2019·Diabetes/metabolism Research and Reviews·Xiaojing LiChenguang Du
Apr 4, 2019·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Thomas A Lutz, Christelle Le Foll
Apr 9, 2019·The Journal of Endocrinology·María F AndreoliMario Perello
May 5, 2020·Basic & Clinical Pharmacology & Toxicology·Hannah Louise ZakariassenThomas Alexander Lutz
Dec 31, 2019·Current Diabetes Reviews·Juan SalazarValmore Bermudez
Feb 9, 2020·Neuropharmacology·Hannah Louise ZakariassenChristelle Le Foll
May 6, 2021·The New England Journal of Medicine·Raj K Goyal
Apr 28, 2021·The European Journal of Neuroscience·Grethe SkovbjergJacob Hecksher-Sørensen
Jul 3, 2021·International Journal of Molecular Sciences·Valentina Annamaria GenchiSebastio Perrini
Jul 15, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lauren M SteinElizabeth G Mietlicki-Baase
Dec 21, 2021·Journal of Obesity & Metabolic Syndrome·Babak DehestaniCarel W le Roux

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