Amylin(1-8) is devoid of anabolic activity in bone

Calcified Tissue International
Maria EllegaardMartin Stahlhut

Abstract

Amylin(1-8), a cyclic peptide consisting of the eight N-terminal amino acids of the 37-amino acid peptide amylin, has been shown to induce proliferation of primary osteoblasts and to induce bone formation in healthy male mice, whereas no data on efficacy in bone disease-related models have been reported. Therefore, we evaluated any effects of amylin(1-8) in ovariectomized rats with established osteopenia, a model for postmenopausal osteoporosis. At doses up to 100 nmol/kg/day, a dose highly effective in healthy mice, amylin(1-8) was unable to increase bone mineral density in ovariectomized rats during an 8-week treatment period. Histomorphometric analysis of the tibia indicated that amylin(1-8) did not change bone histomorphometric parameters. In an attempt to verify any potential biological effects of amylin(1-8), we investigated the efficacy of this peptide in various in vitro assays. Experiments designed to confirm previously published results on the proliferative effects of amylin(1-8) on primary osteoblasts failed to show any response. Amylin(1-8) was able to partially displace (125)I-rat amylin(1-37) from amylin receptors composed of the calcitonin receptor and RAMP1, indicating specific interaction of the peptide with th...Continue Reading

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Jul 6, 2010·Archives of Biochemistry and Biophysics·Jennifer S Walsh, Dennis B Henriksen
Jun 15, 2016·Medicinal Research Reviews·Zaid AmsoMargaret A Brimble
Nov 28, 2012·Molecular and Cellular Endocrinology·I Gutiérrez-RojasP Esbrit
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