Amyloid- and FDG-PET in sporadic Creutzfeldt-Jakob disease: Correlation with pathological prion protein in neuropathology

Prion
Jordi A Matías-GuiuJorge Matías-Guiu

Abstract

The role of positron emission tomography (PET) in Creutzfeldt-Jakob disease is less defined than in other neurodegenerative diseases. We studied the correlation between the uptake of 18F-florbetaben and 18F-fluorodeoxyglucose with pathological prion protein deposition in histopathology in a case. A patient with 80 y old with a rapid neurological deterioration with a confirmed diagnosis of CJD was studied. PET and MRI studies were performed between 13-20 d before the death. A region of interest analysis was performed using Statistical Parametric Mapping. MRI showed atrophy with no other alterations. FDG-PET showed extensive areas of hypometabolism including left frontoparietal lobes as well as bilateral thalamus. Correlation between uptake of 18F-florbetaben and pathological prion protein deposition was r = 0.786 (p < 0.05). Otherwise, correlation between uptake of 18F-FDG and pathological prion protein was r = 0.357 (p = 0.385). Immunohistochemistry with β-amyloid did not show amyloid deposition or neuritic plaques. Our study supports the use of FDG-PET in the assessment of CJD. FDG-PET may be especially useful in cases of suspected CJD and negative MRI. Furthermore, this case report provides more evidence about the behavioral ...Continue Reading

References

Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Oct 3, 2003·British Medical Bulletin·Herbert Budka
Jun 8, 2006·Annual Review of Biochemistry·Fabrizio Chiti, Christopher M Dobson
Apr 1, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·V L VillemagneS J Collins
Sep 4, 2009·Brain Pathology·Vladimir KepeJorge R Barrio
Sep 24, 2009·Brain : a Journal of Neurology·I ZerrP Sanchez-Juan
Dec 18, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Nobuyuki OkamuraKatsumi Doh-ura
Mar 18, 2011·Trends in Biochemical Sciences·Marcus FändrichNikolaus Grigorieff
Apr 12, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Harpreet HyareSimon Mead
Nov 5, 2011·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E-J KimY Jeong
Jun 20, 2012·Lancet Neurology·Gianfranco PuotiPierluigi Gambetti
Jul 17, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Xiao-wei XingSheng-yuan Yu
Mar 4, 2014·Neurología : publicación oficial de la Sociedad Española de Neurología·S Ortega-CuberoM Riverol
Mar 7, 2014·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Federico CaobelliUgo Paolo Guerra
Jun 5, 2015·European Journal of Nuclear Medicine and Molecular Imaging·Elena PrietoJavier Arbizu
Jul 21, 2015·Cellular and Molecular Life Sciences : CMLS·Ellen HubinRabia Sarroukh
Nov 27, 2015·BMC Neurology·Jordi A Matías-GuiuJosé Luis Carreras
Apr 12, 2016·Frontiers in Neurology·Jordi A Matías-GuiuJorge Matías-Guiu
Jun 6, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Jordi A Matías-GuiuJosé Luis Carreras
Jan 26, 2017·Alzheimer Disease and Associated Disorders·Karin P MenteBrian S Appleby

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Citations

Jan 24, 2021·Seminars in Nuclear Medicine·Natasha KrishnadasChristopher C Rowe

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Software Mentioned

Statistics
GraphPad Prism
Image J
Statistical Parametric Mapping
MarsBaR

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