Amyloid Accumulation and Cognitive Decline in Clinically Normal Older Individuals: Implications for Aging and Early Alzheimer's Disease

Journal of Alzheimer's Disease : JAD
Elizabeth C Mormino, Kathryn V Papp

Abstract

The aberrant accumulation of the amyloid protein is a critical and early event in the Alzheimer's disease (AD) cascade. Given the early involvement of this pathological process, it is not surprising that many clinically normal (CN) older individuals demonstrate evidence of abnormal Aβ at postmortem examination and in vivo using either CSF or PET imaging. Converging evidence across multiple research groups suggests that the presence of abnormal Aβ among CN individuals is associated with elevated risk of future clinical impairment and cognitive decline. Amyloid positivity in conjunction with biomarkers of neuronal injury offers further insight into which CN are most at risk for short-term decline. Although in its infancy, tau PET has demonstrated early increases among Aβ+ that will likely be an important indicator of risk among CN. Overall, the detection of early Aβ among CN individuals has provided an important opportunity to understand the contributions of this pathology to age-related cognitive decline and to explore early intervention with disease modifying strategies.

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Jul 1, 1997·Neurobiology of Aging·H Braak, E Braak
Mar 11, 1999·Annals of Neurology·J L Price, J C Morris
Mar 19, 2003·Psychology and Aging·Lars NybergLars-Göran Nilsson
Mar 3, 2004·Annals of Neurology·William E KlunkBengt Långström
Sep 19, 2007·Psychology and Aging·Deborah FinkelNancy L Pedersen
Mar 15, 2008·Brain : a Journal of Neurology·Milos D IkonomovicSteven T DeKosky
Nov 13, 2008·Archives of Neurology·Howard Jay AizensteinWilliam E Klunk
Nov 28, 2008·Annual Review of Psychology·Denise C Park, Patricia Reuter-Lorenz
Dec 24, 2008·Journal of Neuropathology and Experimental Neurology·Peter T NelsonWilliam R Markesbery
Feb 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerKeith A Johnson
Apr 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eric M ReimanRichard J Caselli
Jul 3, 2009·Journal of the International Neuropsychological Society : JINS·Timothy A Salthouse
Oct 9, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Trey HeddenRandy L Buckner
Feb 27, 2010·Annals of Neurology·John C MorrisMark A Mintun
May 27, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Dean F WongMichael J Pontecorvo
Jul 14, 2010·Brain : a Journal of Neurology·Mario A ParraSergio Della Sala
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Bernhard P Staresina, Lila Davachi
Mar 26, 2011·Annals of Neurology·J Alex BeckerKeith A Johnson
May 18, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Peter J SnyderSandra Weintraub
Jun 22, 2011·Neuropsychologia·Dorene M RentzReisa A Sperling
Sep 17, 2011·Journal of the American Geriatrics Society·Rebecca England AmariglioDorene M Rentz
Sep 20, 2011·Journal of the International Neuropsychological Society : JINS·Laura B ZahodneJennifer J Manly
Oct 11, 2011·Trends in Cognitive Sciences·William J Jagust, Elizabeth C Mormino
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Peter T NelsonThomas G Beach
May 1, 2012·Trends in Cognitive Sciences·Lars NybergLars Bäckman
Jul 13, 2012·Neurology·P Murali DoraiswamyUNKNOWN AV45-A11 Study Group
Oct 31, 2012·Annals of Neurology·Susan M LandauUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Citations

Mar 1, 2019·Journal of Alzheimer's Disease : JAD·J Wesson Ashford
Sep 25, 2020·Molecular Neurobiology·Wojciech K PanekNatasha J Olby
May 18, 2020·Journal of Alzheimer's Disease : JAD·Aki KawasakiJulius Popp
Aug 17, 2019·The Indian Journal of Medical Research·Shampa GhoshManchala Raghunath
Sep 21, 2019·Yonsei Medical Journal·Hyung Jun YoonUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 30, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Kimberly D MuellerSterling C Johnson
Feb 10, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nicholas J IzzoSusan M Catalano
Feb 15, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Miriam T AshfordMichael W Weiner
Mar 6, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Claire M EricksonLindsay R Clark
Mar 23, 2021·Journal of Alzheimer's Disease : JAD·Alvaro MirandaCristian Paz
Jun 15, 2021·Chonnam Medical Journal·Hoowon Kim, Ji Yeon Chung
Jul 24, 2021·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Fredrik ÖhmanKathryn V Papp
Aug 3, 2021·Journal of Alzheimer's Disease : JAD·Lucas M WaldenUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 5, 2021·Disease Models & Mechanisms·Larissa TraxlerJerome Mertens
Aug 10, 2021·Journal of Alzheimer's Disease : JAD·Laurens Ansem van de MortelUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Sep 17, 2021·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·Till IlliesUwe Kehler
Oct 23, 2021·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Aron S BuchmanDavid A Bennett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Age-related Dementia

Dementias are a group of conditions, including Alzheimer's disease, vascular dementia, and frontotemporal dementia, characterized by deficiencies in cognitive abilities. Age-related dementia refers to dementias that occur in older individuals, usually 60+ years old, in contrast to early-onset dementia. Follow the latest research on age-related dementia here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Brain Aging

Here is the latest research on intrinsic and extrinsic factors, as well as pathways and mechanisms that underlie aging in the central nervous system.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.