PMID: 25731622Mar 4, 2015Paper

Amyloid β accumulation assessed with ¹¹C-Pittsburgh compound B PET and postmortem neuropathology

Current Alzheimer Research
Hiroyuki HatsutaShigeo Murayama

Abstract

¹¹C-Pittsburgh compound B (PiB) uptake in PET images is frequently used to analyze β amyloid (Aβ) deposition in living individuals, but its correlation with histologically determined Aβ has not been examined. Six individuals with dementia underwent PiB-PET imaging, and their brains were analyzed neuropathologically (mean interval between imaging and death: 816 days; PiB positive:negative, 3:3; male:female, 3:3; mean age: 84.0 years). PiB uptake (reported as standardized uptake value ratio [SUVR]) was analyzed in 11 cortical regions and 10 subcortical grey matter areas and compared with the Aβ load (% area [the percentage of total area positive for Aβ] and number of neuritic plaques) seen with immunohistochemical staining with an anti-Aβ 11-28 antibody. Two PiB-positive subjects had abundant neuritic plaques and were diagnosed with Alzheimer’s disease (AD). SUVR and % area were strongly correlated in the cortical regions of these subjects (subject 1: r = 0.65, p = 0.03; subject 2: r = 0.80, p = 0.003). The other PiBpositive subject (subject 3) showed focal PiB uptake. In subject 3 and the 3 PiB-negative subjects (subjects 4-6), there was no correlation between regional SUVR and % area or neuritic plaques. PiB uptake was not corr...Continue Reading

Citations

Oct 1, 2015·Brain : a Journal of Neurology·Andre AltmannUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Nov 4, 2015·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·David A LoewensteinRanjan Duara
Dec 3, 2016·Journal of the International Neuropsychological Society : JINS·Emily C EdmondsUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Aug 6, 2019·Developmental Neurobiology·Eric E AbrahamsonMilos D Ikonomovic
May 8, 2018·Annals of Nuclear Medicine·Julia SauerbeckTakamichi Murakami
Apr 5, 2018·Journal of Alzheimer's Disease : JAD·Noora M ScheininJuha O Rinne

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