Amyloid β and free heme: bloody new insights into the pathogenesis of Alzheimer's disease

Neural Regeneration Research
Jörg FlemmigA Alia

Abstract

The cerebral formation of Amyloid β (Aβ) is a critical pathological feature of Alzheimer's disease (AD). An accumulation of this peptide as senile plaques (SP) was already reported by Alois Alzheimer, the discoverer of the disease. Yet the exact contribution of Aβ to AD development remains elusive. Moreover, while extensive cerebral Aβ formation leads to fibril formation in many species, AD-like symptoms apparently depend on the highly conserved N-terminal residues R5, Y10 and H13. The amino acids were also shown to lead to the formation of Aβ-heme complexes, which exhibit peroxidase activity in the presence of H2O2. Taking together these observations we propose that the formation and enzymatic activity of the named complexes may represent an essential aspect of AD pathology. Furthermore, Aβ is also known to lead to cerebral micro-vessel destruction (CAA) as well as to hemolytic events. Thus we suggest that the Aβ-derived cerebral accumulation of blood-derived free heme represents a likely precondition for the subsequent formation of Aβ-heme complexes.

References

Jan 1, 1997·Free Radical Biology & Medicine·W R Markesbery
Sep 2, 1997·Proceedings of the National Academy of Sciences of the United States of America·M A SmithG Perry
Jun 28, 2003·Biochimica Et Biophysica Acta·Rajadas JayakumarJoseph M Rifkind
Jul 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hani Atamna, William H Frey
Mar 29, 2008·BMC Evolutionary Biology·Noeleen B LoughranMary J O'Connell
Dec 15, 2010·Journal of the American Chemical Society·Debajyoti Pramanik, Somdatta Ghosh Dey
May 1, 2013·Current Alzheimer Research·Debby Van DamPeter Paul De Deyn
Oct 12, 2013·Folia Neuropathologica·R A Armstrong
Dec 20, 2013·Acta Neuropathologica Communications·Youssra K Al-HilalyLouise C Serpell
Jan 1, 2014·Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists·T A MendelG M Szpak
Mar 26, 2014·Neuroscience Bulletin·Zhichun Chen, Chunjiu Zhong
Sep 7, 2014·Biochemical and Biophysical Research Communications·Naihao LuYi-Yuan Peng
Sep 25, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Soumya MukherjeeSomdatta Ghosh Dey
Oct 5, 2014·Biochimica Et Biophysica Acta·Stéphane BastianettoRémi Quirion
Aug 8, 2015·Accounts of Chemical Research·Chandradeep GhoshSomdatta Ghosh Dey
Jan 29, 2016·Journal of Thrombosis and Haemostasis : JTH·A H Schmaier
Feb 28, 2016·Biological Research·Claudia SalazarAdrián G Palacios
Mar 24, 2016·Molecular Biology and Evolution·Sudhir KumarKoichiro Tamura
Mar 26, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bruno DuboisUNKNOWN Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclin
May 31, 2016·F1000Research·Lewis BussAndré Strydom
Jul 30, 2016·Proceedings of the National Academy of Sciences of the United States of America·Marielle Aulikki WältiRoland Riek
Aug 3, 2016·Cold Spring Harbor Perspectives in Medicine·Robert Tycko
Mar 4, 2017·Progress in Molecular Biology and Translational Science·F AkhterS S Yan
Jan 15, 2018·Journal of Alzheimer's Disease : JAD·Elisabeth ChizianeJörg Flemmig

❮ Previous
Next ❯

Citations

Jun 4, 2020·Phytotherapy Research : PTR·Milad AshrafizadehKwang Seok Ahn
Apr 19, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Weili KongJunhao Wu
Apr 10, 2020·The Biochemical Journal·Margaret PhillipsKonstantin Pervushin
Dec 6, 2019·Chemical Science·Ishita PalSomdatta Ghosh Dey
Dec 15, 2020·The FEBS Journal·Olivia MayMarie Frimat
Apr 14, 2020·ACS Omega·Tony KöhlerJulian Thiele
Aug 30, 2021·Molecular Neurodegeneration·M Mahafuzur Rahman, Christofer Lendel

❮ Previous
Next ❯

Methods Mentioned

BETA
NMR

Software Mentioned

PyMOL Molecular Graphics System
MEGA7

Related Concepts

Related Feeds

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Related Papers

Journal of Alzheimer's Disease : JAD
Elisabeth ChizianeJörg Flemmig
Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Can YuanZhonghong Gao
Nihon rinsho. Japanese journal of clinical medicine
T Ishii
© 2022 Meta ULC. All rights reserved