Amyloid-Beta Induced Changes in Vesicular Transport of BDNF in Hippocampal Neurons

Neural Plasticity
Bianca SeifertTanja Brigadski

Abstract

The neurotrophin brain derived neurotrophic factor (BDNF) is an important growth factor in the CNS. Deficits in transport of this secretory protein could underlie neurodegenerative diseases. Investigation of disease-related changes in BDNF transport might provide insights into the cellular mechanism underlying, for example, Alzheimer's disease (AD). To analyze the role of BDNF transport in AD, live cell imaging of fluorescently labeled BDNF was performed in hippocampal neurons of different AD model systems. BDNF and APP colocalized with low incidence in vesicular structures. Anterograde as well as retrograde transport of BDNF vesicles was reduced and these effects were mediated by factors released from hippocampal neurons into the extracellular medium. Transport of BDNF was altered at a very early time point after onset of human APP expression or after acute amyloid-beta(1-42) treatment, while the activity-dependent release of BDNF remained unaffected. Taken together, extracellular cleavage products of APP induced rapid changes in anterograde and retrograde transport of BDNF-containing vesicles while release of BDNF was unaffected by transgenic expression of mutated APP. These early transport deficits might lead to permanently ...Continue Reading

References

Jul 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Klein
Jun 26, 1998·Brain Research. Brain Research Reviews·B Connor, M Dragunow
Oct 24, 1998·Trends in Neurosciences·C A Altar, P S DiStefano
Jan 22, 2001·The Journal of Biological Chemistry·S J MowlaR A Murphy
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
May 4, 2002·Molecular and Cellular Neurosciences·Kirsty L SpaldingAlan R Harvey
Mar 29, 2003·Learning & Memory·Bai Lu
May 2, 2003·Journal of Neuropathology and Experimental Neurology·Alex KruttgenJoachim Weis
Aug 23, 2003·Trends in Biochemical Sciences·Phoebe Harjes, Erich E Wanker
Mar 5, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Orly LazarovSangram S Sisodia
Aug 19, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Tanja BrigadskiVolkmar Lessmann
Jan 24, 2007·Journal of Neuroscience Research·Rafal Butowt, Christopher S von Bartheld
Mar 30, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jim P DompierreFrédéric Saudou
Jul 31, 2007·Current Biology : CB·Dai HoriuchiWilliam M Saxton
Sep 28, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard KolarowVolkmar Lessmann
Feb 8, 2008·Genes, Brain, and Behavior·K SchindowskiL Buée
Jul 25, 2008·The Journal of Biological Chemistry·Gopal Thinakaran, Edward H Koo
Aug 19, 2008·Brain Research Reviews·Lucia Tapia-ArancibiaSandor Arancibia
Jan 13, 2009·Nature Neuroscience·Jianmin YangBarbara L Hempstead
Jan 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Guhan NagappanBai Lu

❮ Previous
Next ❯

Citations

Jul 20, 2016·BioMed Research International·Peiqing ChenMing Yin
Mar 8, 2017·Journal of Neurochemistry·Roland Brandt, Lidia Bakota
Nov 4, 2017·International Journal of Molecular Sciences·Tadahiro NumakawaNaoki Adachi
Apr 30, 2020·Acta Neuropathologica Communications·Ahmed ElsherbiniErhard Bieberich
May 30, 2017·Neural Regeneration Research·Tuane Bazanella SampaioSimone Pinton
Sep 19, 2020·Cell and Tissue Research·Tanja Brigadski, Volkmar Leßmann
May 22, 2018·Progress in Neuro-psychopharmacology & Biological Psychiatry·Konstantin YenkoyanMichail Aghajanov

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
FCS
transfection
electron microscopy
chip
ubiquitination

Software Mentioned

MetaMorph
VisiView
SPSS
Zen

Related Concepts

Related Feeds

Astrocytes & Neurodegeneration

Astrocytes are important for the health and function of the central nervous system. When these cells stop functioning properly, either through gain of function or loss of homeostatic controls, neurodegenerative diseases can occur. Here is the latest research on astrocytes and neurodegeneration.

Alzheimer's Disease: Endosomes

Dysfunctional endosomal trafficking may be associated with Alzheimer’s disease (AD) pathology. Targeting the endosome may advance treatment options for AD. Here is the latest research on endosomes and AD.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Astrocytes & Amyloid

Astrocytes are thought to play a role in amyloid production and have been implicated in neurodegenerative diseases such as Alzheimer’s disease. Here is the latest research on the relationship between astrocytes and amyloid.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.