Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease

doi:10.3389/fneur.2019.01140

Amyloid Beta Oligomers Target to Extracellular and Intracellular Neuronal Synaptic Proteins in Alzheimer's Disease

Frontiers in Neurology

Nov 1, 2019

Yu DingYuesong Gong

PMID: 31736856

DOI: 10.3389/fneur.2019.01140

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Abstract

Introduction: β-Amyloid protein (Aβ) putatively plays a seminal role in synaptic loss in Alzheimer's disease (AD). While there is no consensus regarding the synaptic-relevant species of Aβ, it is known that Aβ oligomers (AβOs) are noticeably increased in the early stages of AD, localizi...read more

Mentioned in this Paper

Na(+)-K(+)-Exchanging ATPase

Aging

Alzheimer's Disease

Western Blotting

High Pressure Liquid Chromatography Procedure

Frontal Lobe

Neurons

Synapses

Ultracentrifugation

Postsynaptic density proteins

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