PMID: 8592647Sep 29, 1995Paper

Amyloid beta peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3 beta in rat hippocampal neurons

Neuroscience Letters
A TakashimaK Imahori

Abstract

Exogenous application of synthetic amyloid beta protein (A beta) is known to induce neurotoxic effects in rat hippocampal culture. We report here that A beta (25-35) induces accumulation of amyloid precursor protein (APP) derivatives in the cytoplasm of neurons. At the same time, the level of the secreted form of APP released into the culture medium decreases. Tau protein kinase I/glycogen synthase kinase-3 beta (TPK I/GSK-3 beta) antisense oligonucleotide blocked APP accumulation and prevented neuronal death. These results provide evidence that APP accumulation after A beta treatment is regulated by TPK I/GSK-3 beta. A beta neurotoxicity is probably mediated via phosphorylation of tau by TPK I/GSK-3 beta, resulting in an impairment of axonal transport, and cytoplasmic accumulation of APP.

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Citations

Jan 20, 2011·Basic Research in Cardiology·Karina GrubeThomas Krieg
Sep 1, 2006·Neurochemical Research·Richard S JopeEléonore Beurel
Jun 10, 2009·Molecular Neurobiology·Jia Luo
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Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·A TakashimaB Wolozin
Oct 22, 2008·European Archives of Psychiatry and Clinical Neuroscience·Camila Teixeira MendesWagner Farid Gattaz
Apr 28, 2005·Free Radical Biology & Medicine·Mauro SalviAntonio Toninello
Jun 9, 2007·Journal of Neurochemistry·Lilia EspadaAlbert Tauler
Feb 9, 2006·Neurobiology of Aging·Patrizia De SarnoRichard S Jope
May 9, 2014·Frontiers in Molecular Neuroscience·Seiko Ikezu, Tsuneya Ikezu
Jul 7, 2012·PloS One·Marie Néant-FeryIsabelle Caillé
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Jul 6, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Philip Washbourne
Jan 7, 2010·Journal of Neurochemistry·Maria Cristina RosiFiorella Casamenti
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Nov 1, 2005·The Journal of Biological Chemistry·Shinichi KosugaMasaya Imoto
Mar 8, 2020·International Journal of Molecular Sciences·Antaripa BhattacharyaDaniela Sarnataro
Jan 16, 2014·Journal of Cell Science·Barbara PianuFrancesca Bartolini
Aug 19, 2008·Molecular and Cellular Neurosciences·Katja KanninenJari Koistinaho

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