Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease.

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Alex E RoherMarwan N Sabbagh

Abstract

We evaluated the amounts of amyloid beta (Abeta)) peptides in the central nervous system (CNS) and in reservoirs outside the CNS and their potential impact on Abeta plasma levels and Alzheimer's disease (AD) pathology. Amyloid beta levels were measured in (1) the plasma of AD and nondemented (ND) controls in a longitudinal study, (2) the plasma of a cohort of AD patients receiving a cholinesterase inhibitor, and (3) the skeletal muscle, liver, aorta, platelets, leptomeningeal arteries, and in gray and white matter of AD and ND control subjects. Plasma Abeta levels fluctuated over time and among individuals, suggesting continuous contributions from brain and peripheral tissues and associations with reactive circulating proteins. Arteries with atherosclerosis had larger amounts of Abeta40 than disease-free vessels. Inactivated platelets contained more Abeta peptides than activated ones. Substantially more Abeta was present in liver samples from ND patients. Overall, AD brain and skeletal muscle contained increased levels of Abeta. Efforts to use plasma levels of Abeta peptides as AD biomarkers or disease-staging scales have failed. Peripheral tissues might contribute to both the circulating amyloid pool and AD pathology within th...Continue Reading

References

Feb 28, 1991·Biochemical and Biophysical Research Communications·W E Van NostrandD D Cunningham
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D J SelkoeT Oltersdorf
Aug 4, 1995·Biochemical and Biophysical Research Communications·M ChenH L Fernandez
Jun 9, 1995·The Journal of Biological Chemistry·Q X LiC L Masters
Feb 23, 1996·The Journal of Biological Chemistry·Y M KuoA E Roher
Dec 20, 1996·The Journal of Biological Chemistry·A L BiereD J Selkoe
May 12, 1997·FEBS Letters·J GhisoB Frangione
Apr 20, 1999·Biochemical and Biophysical Research Communications·Y M KuoA E Roher
Feb 19, 2000·Biochemical and Biophysical Research Communications·Y M KuoA E Roher
Aug 7, 2001·Journal of Neuropathology and Experimental Neurology·T MoriM J Mullan
Jan 5, 2002·Neurobiology of Aging·P Grammas, R Ovase
Sep 10, 2002·Dementia and Geriatric Cognitive Disorders·Hans BasunSteven Younkin
Nov 6, 2002·Journal of the Neurological Sciences·Barbara BorroniAlessandro Padovani
Jan 22, 2003·Seminars in Thrombosis and Hemostasis·Wade R Wilkerson, David C Sane
Sep 27, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Alex E RoherThomas G Beach
Dec 25, 2003·Journal of Neuropathology and Experimental Neurology·Dietmar Rudolf ThalOtmar D Wiestler
Aug 11, 2004·Angiogenesis·Daniel ParisMichael Mullan
Aug 24, 2004·The Journal of Biological Chemistry·Jorge GhisoBlas Frangione
Aug 17, 2005·Microscopy Research and Technique·Valerie Askanas, W King Engel
Sep 15, 2005·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Magnus Sjögren, Kaj Blennow
Dec 7, 2005·Proceedings of the National Academy of Sciences of the United States of America·Feng XuWilliam E Van Nostrand
May 27, 2006·Cardiovascular & Hematological Disorders Drug Targets·D M JansG R Y De Meyer
Jul 1, 2006·The Journal of Physiology·Hugh A Pearson, Chris Peers

❮ Previous
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Citations

Jun 12, 2013·Journal of Molecular Modeling·Wichien Sang-aroon, Vithaya Ruangpornvisuti
Jul 26, 2013·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Semagacestat Study Group
Jun 8, 2012·Cold Spring Harbor Perspectives in Medicine·Colin L Masters, Dennis J Selkoe
Jul 11, 2012·International Journal of Alzheimer's Disease·Y WangK Henriksen
Dec 4, 2012·Stroke; a Journal of Cerebral Circulation·Laibaik ParkCostantino Iadecola
Sep 19, 2012·Immunity & Ageing : I & a·Silvia CatricalaGiovanni Ricevuti
Mar 9, 2013·Alzheimer's Research & Therapy·Jon B ToledoJohn Q Trojanowski
Mar 4, 2014·PloS One·Nina S GowertMargitta Elvers
Apr 14, 2010·Biomarkers in Medicine·Madhav Thambisetty, Simon Lovestone
Feb 19, 2013·Brain Structure & Function·Sarah E Crowe, Graham C R Ellis-Davies
Nov 15, 2011·Neurodegenerative Disease Management·Milton C Biagioni, James E Galvin
Apr 1, 2014·Biological Trace Element Research·Sreeram Krishnan, P Rani
Aug 15, 2014·Acta Neuropathologica·Andrew D WattLuke A Miles
Nov 25, 2011·International Journal of Alzheimer's Disease·Seema PatelMarwan Sabbagh
Jul 3, 2010·Science China. Life Sciences·YanPeng ZhengTao Hong
Nov 15, 2014·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shana M KatzmanUNKNOWN Health, Aging, and Body Composition Study
Sep 18, 2015·Frontiers in Neurology·Aaron Ritter, Jeffrey Cummings
Jul 2, 2015·Molecular BioSystems·Raúl González-DomínguezJosé Luis Gómez-Ariza
Jan 12, 2010·Maturitas·Charlotte L AllanKlaus P Ebmeier
Mar 19, 2015·Frontiers in Cellular Neuroscience·Ilaria CanobbioGiordano Pula
Mar 23, 2013·Diabetes·Naoyuki Sato, Ryuichi Morishita
May 7, 2016·Nature Communications·Simon J BeckHeng Du
Jun 1, 2016·Scientific Reports·Shorena JanelidzeOskar Hansson
Feb 11, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mutsumi MizoiKazuei Igarashi
Oct 4, 2016·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Philipe de Souto BarretoUNKNOWN MAPT Study Group
Jun 30, 2009·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Tyler A Kokjohn, Alex E Roher
Nov 1, 2016·Molecular Neurobiology·Janine GronewoldDirk M Hermann
Nov 2, 2016·Molecular Biology of the Cell·Giovanna CeniniWolfgang Voos
Mar 9, 2017·Journal of Alzheimer's Disease : JAD·Prashant BharadwajGiuseppe Verdile

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