PMID: 11331424May 2, 2001Paper

Amyloid beta peptides mediate hypoxic augmentation of Ca(2+) channels

Journal of Neurochemistry
K N Green, Chris Peers

Abstract

Clinical studies indicate that neurodegeneration caused by Alzheimer's amyloid beta peptide (AbetaP) formation can be triggered or induced by prolonged (chronic) hypoxia. Here, we demonstrate that 24-h culture of PC12 cells in 10% O(2) leads to induction of a Cd(2+)-resistant Ca(2+) influx pathway and selective potentiation of L-type Ca(2+) current. Both effects were suppressed or prevented by a monoclonal antibody raised against the N'-terminus of AbetaP, and were fully mimicked by AbetaP(1-40 and) AbetaP(1-42), but not by AbetaP(40-1). Potentiation of L-type currents was also induced by exposure to AbetaP(25-35). Our results indicate that hypoxia induces enhancement of Ca(2+) channels, which is mediated by increased AbetaP formation.

References

Apr 1, 1992·Physiological Reviews·W Jelkmann
May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong
Apr 1, 1994·Trends in Neurosciences·J López-Barneo
Dec 1, 1993·Stroke; a Journal of Cerebral Circulation·K Kogure, H Kato
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·N ArispeE Rojas
Aug 1, 1996·Stroke; a Journal of Cerebral Circulation·J T MoroneyT K Tatemichi
Jul 1, 1996·Physiological Reviews·H F Bunn, R O Poyton
Nov 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M YokotaN Minami
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·K Johnson-WoodL McConlogue
Nov 5, 1997·Annals of the New York Academy of Sciences·K JendroskaS Patt
Jan 14, 1998·Trends in Pharmacological Sciences·C Peers
Jun 5, 1998·The Journal of Biological Chemistry·S K RheeR Lal
Jul 24, 1998·Biochemical and Biophysical Research Communications·S C Taylor, C Peers
Oct 28, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y LiuD Schubert

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Citations

Dec 18, 2001·Journal of Neuroscience Research·A Szutowicz
Dec 24, 2003·Teratogenesis, Carcinogenesis, and Mutagenesis·Eduardo CemeliDiana Anderson
Feb 13, 2013·Neurotoxicity Research·Mak Adam Daulatzai
Mar 24, 2004·Biochemical Pharmacology·Lucy C HammondChristopher J Bowmer
Oct 2, 2001·Archives of Medical Research·R B MaccioniL Barbeito
Dec 11, 2002·Journal of Neurochemistry·Nicola J WebsterPeter F T Vaughan
Dec 3, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Chris PeersHugh A Pearson
Nov 17, 2007·Acta Physiologica·R H S Westerink, A G Ewing
Aug 23, 2012·PloS One·Maya A KoikeFrank M LaFerla
Aug 11, 2004·Molecular Aspects of Medicine·Michael R Duchen
Sep 29, 2007·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Grace E Stutzmann
Apr 13, 2005·The Journal of Biological Chemistry·Stephen T BrownIan M Fearon
Aug 5, 2009·Journal of Cellular and Molecular Medicine·Kim N Green
Oct 23, 2009·Annals of the New York Academy of Sciences·Chris PeersJohn P Boyle
May 4, 2013·British Journal of Pharmacology·V Nimmrich, A Eckert
May 20, 2003·Journal of Neurochemistry·I F SmithC Peers
Oct 21, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jason L ScraggChris Peers
Aug 21, 2007·Essays in Biochemistry·Chris PeersJohn P Boyle
Nov 8, 2001·American Journal of Physiology. Cell Physiology·S C TaylorC Peers
May 5, 2021·Translational Neurodegeneration·Xiaohuan XiaJialin Zheng
Jan 5, 2005·Archives of Biochemistry and Biophysics·Paul Waring
May 11, 2007·Biochimica Et Biophysica Acta·Nelson ArispeOlga Simakova

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