Amyloid Beta-Protein and Neural Network Dysfunction

Journal of Neurodegenerative Diseases
Fernando Peña-Ortega

Abstract

Understanding the neural mechanisms underlying brain dysfunction induced by amyloid beta-protein (Aβ) represents one of the major challenges for Alzheimer's disease (AD) research. The most evident symptom of AD is a severe decline in cognition. Cognitive processes, as any other brain function, arise from the activity of specific cell assemblies of interconnected neurons that generate neural network dynamics based on their intrinsic and synaptic properties. Thus, the origin of Aβ-induced cognitive dysfunction, and possibly AD-related cognitive decline, must be found in specific alterations in properties of these cells and their consequences in neural network dynamics. The well-known relationship between AD and alterations in the activity of several neural networks is reflected in the slowing of the electroencephalographic (EEG) activity. Some features of the EEG slowing observed in AD, such as the diminished generation of different network oscillations, can be induced in vivo and in vitro upon Aβ application or by Aβ overproduction in transgenic models. This experimental approach offers the possibility to study the mechanisms involved in cognitive dysfunction produced by Aβ. This type of research may yield not only basic knowled...Continue Reading

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Citations

Apr 13, 2020·Molecular Biology Reports·Seyedeh Nahid FotuhiMahnaz Talebi
Apr 26, 2014·Pediatric Hematology and Oncology·Emma HonkaniemiBritt Gustafsson
Oct 16, 2016·Applied Microbiology and Biotechnology·Salwa Mansur AliNaveed Ahmed Khan
Sep 19, 2019·Neural Plasticity·Rebeca Hernández-SotoFernando Peña-Ortega
Jan 28, 2017·International Journal of Peptides·Ernesto Flores-Martínez, Fernando Peña-Ortega
Jul 24, 2013·International Journal of Peptides·Armando I Gutiérrez-LermaFernando Peña-Ortega
Aug 1, 2015·Behavioural Neurology·Karla Salgado-PugaFernando Peña-Ortega
Jul 6, 2021·Frontiers in Molecular Neuroscience·Yuniesky Andrade-Talavera, Antonio Rodríguez-Moreno

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Methods Mentioned

BETA
transgenic

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