PMID: 11343827May 10, 2001Paper

Amyloid beta protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype

Neuroscience Letters
D MannTakeshi Iwatsubo

Abstract

Amyloid beta protein (Abeta) deposition was investigated in the frontal cortex of 54 autopsy cases of frontotemporal lobar degeneration (FTLD) using methenamine silver staining, and immunohistochemistry employing the monoclonal end-specific antibodies BC05 and BA27 to visualize deposits containing Abeta(42(43)) and Abeta(40), respectively. Abeta was detected in 14 (26%) patients, nearly always in the form of diffuse Abeta(42(43)) containing plaques though some cored, neuritic plaques with trace amounts of Abeta(40) were occasionally seen. The 14 patients showing Abeta deposits were significantly older at onset of illness than those 40 patients without Abeta. It was only possible to genotype 46/54 cases, 16 of whom bore at least one copy of the Apolipoprotein E (APOE) epsilon4 allele, giving an allele frequency of 20%. Possession of APOE epsilon4 allele was significantly associated with deposition of Abeta such that 10/16 epsilon4 allele bearers had Abeta deposits. Eight of these ten patients showed only mild to moderate amounts of Abeta, but in two patients, one homozygous and one heterozygous for epsilon4 allele, there was extensive neuritic plaque and neurofibrillary tangle formation. In contrast, only few non-epsilon4 allele...Continue Reading

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Citations

Aug 9, 2013·Acta Neuropathologica·David M A Mann, John Hardy
Feb 21, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S G LindquistJ E Nielsen
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·Y A L PijnenburgP Scheltens
Mar 21, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Y A L PijnenburgP Scheltens
Nov 21, 2013·Acta Neuropathologica Communications·Yvonne S DavidsonDavid M A Mann
Oct 22, 2005·Lancet Neurology·David NearyDavid Mann
May 12, 2007·Brain Pathology·John van Swieten, Maria Grazia Spillantini
May 28, 2014·Neuropathology and Applied Neurobiology·Andrew C RobinsonDavid M A Mann
Mar 26, 2002·Brain : a Journal of Neurology·S M Pickering-BrownD M A Mann
Mar 10, 2016·International Journal of Molecular Sciences·Yazan S BatarsehAmal Kaddoumi
Oct 14, 2009·Neuropathology and Applied Neurobiology·S M Pickering-Brown
Nov 13, 2004·Cognitive, Affective & Behavioral Neuroscience·Nicole A RobertsRobert W Levenson
Apr 23, 2005·Clinical Chemistry·Niki S M SchoonenboomMarinus A Blankenstein
Aug 2, 2002·Current Opinion in Neurology·Sonia M Rosso, John C van Swieten
Nov 8, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Chiho IshidaMasahito Yamada
Feb 7, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christopher KobyleckiKarl Herholz

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