Abstract
Amyloid beta protein (Abeta) deposition was investigated in the frontal cortex of 54 autopsy cases of frontotemporal lobar degeneration (FTLD) using methenamine silver staining, and immunohistochemistry employing the monoclonal end-specific antibodies BC05 and BA27 to visualize deposits containing Abeta(42(43)) and Abeta(40), respectively. Abeta was detected in 14 (26%) patients, nearly always in the form of diffuse Abeta(42(43)) containing plaques though some cored, neuritic plaques with trace amounts of Abeta(40) were occasionally seen. The 14 patients showing Abeta deposits were significantly older at onset of illness than those 40 patients without Abeta. It was only possible to genotype 46/54 cases, 16 of whom bore at least one copy of the Apolipoprotein E (APOE) epsilon4 allele, giving an allele frequency of 20%. Possession of APOE epsilon4 allele was significantly associated with deposition of Abeta such that 10/16 epsilon4 allele bearers had Abeta deposits. Eight of these ten patients showed only mild to moderate amounts of Abeta, but in two patients, one homozygous and one heterozygous for epsilon4 allele, there was extensive neuritic plaque and neurofibrillary tangle formation. In contrast, only few non-epsilon4 allele...Continue Reading
References
Jan 1, 1992·Acta Neuropathologica·D M MannD Neary
Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Feb 5, 1990·Neuroscience Letters·D M Mann, D Jones
Sep 1, 1987·Archives of Gerontology and Geriatrics·A Brun
Jul 1, 1994·Neuron·T IwatsuboY Ihara
Apr 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry
Jun 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·D M MannD Neary
Jul 1, 1996·Neurology·M GrossmanK M Robinson
Jun 1, 1997·Annals of Neurology·N L FosterS Gilman
Dec 17, 1998·Neurology·D NearyD F Benson
Mar 11, 1999·Annals of Neurology·J L Price, J C Morris
Mar 17, 1999·Neuroscience Letters·H HouldenJ Hardy
Apr 29, 1999·Brain : a Journal of Neurology·T D BirdG D Schellenberg
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·I D'SouzaG D Schellenberg
Sep 13, 2000·Neurogenetics·M G SpillantiniM Goedert
Citations
Jul 25, 2009·Der Nervenarzt·M ZintlH-H Klünemann
Aug 9, 2013·Acta Neuropathologica·David M A Mann, John Hardy
May 4, 2002·Neuroscience Letters·E K GreenD M A Mann
Jan 15, 2004·Neuropathology and Applied Neurobiology·S TaniguchiD M A Mann
Mar 6, 2007·Alzheimer Disease and Associated Disorders·Maria I BehrensNigel J Cairns
Feb 21, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·S G LindquistJ E Nielsen
Jan 20, 2006·Journal of Neurology, Neurosurgery, and Psychiatry·Y A L PijnenburgP Scheltens
Mar 21, 2007·Journal of Neurology, Neurosurgery, and Psychiatry·Y A L PijnenburgP Scheltens
Aug 30, 2008·BMC Neurology·Agnes A LutyPeter R Schofield
Nov 21, 2013·Acta Neuropathologica Communications·Yvonne S DavidsonDavid M A Mann
Aug 4, 2009·Journal of Neural Transmission·Petra SteinackerMarkus Otto
Jul 27, 2006·Neuropathology and Applied Neurobiology·A-M ShiarliD M A Mann
Oct 22, 2005·Lancet Neurology·David NearyDavid Mann
May 12, 2007·Brain Pathology·John van Swieten, Maria Grazia Spillantini
May 28, 2014·Neuropathology and Applied Neurobiology·Andrew C RobinsonDavid M A Mann
Mar 26, 2002·Brain : a Journal of Neurology·S M Pickering-BrownD M A Mann
Apr 3, 2014·Acta Neuropathologica Communications·Yasuyuki OhtaJean-Pierre Julien
Mar 10, 2016·International Journal of Molecular Sciences·Yazan S BatarsehAmal Kaddoumi
Oct 14, 2009·Neuropathology and Applied Neurobiology·S M Pickering-Brown
Nov 13, 2004·Cognitive, Affective & Behavioral Neuroscience·Nicole A RobertsRobert W Levenson
Apr 23, 2005·Clinical Chemistry·Niki S M SchoonenboomMarinus A Blankenstein
Feb 18, 2018·Neurology·Sang Won SeoWilliam W Seeley
Aug 2, 2002·Current Opinion in Neurology·Sonia M Rosso, John C van Swieten
May 11, 2017·Oncotarget·Wen-Hua SuYong Ji
Nov 8, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Chiho IshidaMasahito Yamada
Feb 7, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christopher KobyleckiKarl Herholz