Feb 20, 1987

Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus

Science
R E TanziR L Neve

Abstract

The amyloid beta protein has been identified as an important component of both cerebrovascular amyloid and amyloid plaques of Alzheimer's disease and Down syndrome. A complementary DNA for the beta protein suggests that it derives from a larger protein expressed in a variety of tissues. Overexpression of the gene in brain tissue from fetuses with Down syndrome (trisomy 21) can be explained by dosage since the locus encoding the beta protein maps to chromosome 21. Regional localization of this gene by both physical and genetic mapping places it in the vicinity of the genetic defect causing the inherited form of Alzheimer's disease.

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Mentioned in this Paper

Chromosomes, Human, Pair 21
Establishment and Maintenance of Localization
Familial Alzheimer Disease (FAD)
APP protein, human
Amyloidosis
Transcription, Genetic
Brain
Plaque, Amyloid
Thyroid Hormone Plasma Membrane Transport Defect
Alzheimer's Disease

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