Amyloid beta protein precursor is a mitogen

Biochemical and Biophysical Research Communications
D SchubertT Oltersdorf

Abstract

The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.

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