PMID: 2502115DOI: 10.1016/0006-291x(89)91965-7Jul 14, 1989Paper
Amyloid beta protein precursor is a mitogen
Biochemical and Biophysical Research Communications
D SchubertT Oltersdorf
Abstract
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
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