PMID: 2113416May 7, 1990Paper

Amyloid beta-protein precursor is associated with extracellular matrix

Brain Research
F G KlierD Schubert

Abstract

The ultrastructural distribution of the amyloid beta-protein precursor (ABPP) in cultures of a neuronal cell line is examined. ABPP is associated with the extensive extracellular matrix (ECM) secreted by these cells. The possible role of matrix associated ABPP in the pathogenesis of Alzheimer's disease is discussed.

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