Amyloid causes intermittent network disruptions in cognitively intact older subjects

Brain Imaging and Behavior
Susanne G Mueller

Abstract

Recent findings in AD models but also human patients suggest that amyloid can cause intermittent neuronal hyperactivity. The overall goal of this study was to use dynamic fMRI analysis combined with graph analysis to a) characterize the graph analytical signature of two types of intermittent hyperactivity (spike-like (spike) and hypersynchronus-like (synchron)) in simulated data and b) to attempt to identify one of these signatures in task-free fMRIs of cognitively intact subjects (CN) with or without increased brain amyloid. The toolbox simtb was used to generate 33 data sets with 2 short spike events, 33 with 2 synchron and 33 baseline data sets. A combination of sliding windows, hierarchical cluster analysis and graph analysis was used to characterize the spike and the synchron signature. Florbetapir-F18 PET and task-free 3 T fMRI was acquired in 49 CN (age = 70.7 ± 6.4). Processing the real data with the same approach as the simulated data identified phases whose graph analytical signature resembled that of the synchron signature in the simulated data. The duration of these phases was positively correlated with amyloid load (r = 0.42, p < 0.05) and negatively with memory performance (r = -0.43, p < 0.05). In conclusion, amy...Continue Reading

References

May 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Edward A SternBradley T Hyman
Dec 18, 2008·Dementia and Geriatric Cognitive Disorders·M LiedorpC J Stam
Oct 13, 2009·NeuroImage·Mikail Rubinov, Olaf Sporns
May 27, 2010·Dementia and Geriatric Cognitive Disorders·Maarten LiedorpPhilip Scheltens
Nov 27, 2010·Dementia and Geriatric Cognitive Disorders·Lieke L SmitsWiesje M van der Flier
Feb 5, 2011·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Richard WennbergDouglas Cheyne
Apr 5, 2011·NeuroImage·Mikail Rubinov, Olaf Sporns
Sep 6, 2011·NeuroImage·Xiaoqian J ChaiSusan Whitfield-Gabrieli
Jan 1, 2011·Brain Connectivity·Vesa KiviniemiJuha Nikkinen
Apr 12, 2012·Nature Communications·Christine GrienbergerArthur Konnerth
May 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Marc Aurel BuscheArthur Konnerth
May 31, 2012·Brain Connectivity·Susan Whitfield-Gabrieli, Alfonso Nieto-Castanon
Jul 5, 2012·PloS One·David T JonesClifford R Jack
Jul 5, 2012·Cold Spring Harbor Perspectives in Medicine·Lennart Mucke, Dennis J Selkoe
Aug 8, 2012·Proceedings of the National Academy of Sciences of the United States of America·Pascal E SanchezLennart Mucke
Nov 14, 2012·Cerebral Cortex·Elena A AllenVince D Calhoun
Feb 5, 2013·NeuroImage·Catie ChangJeff H Duyn
Apr 12, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Corey J KellerAshesh D Mehta
May 21, 2013·Neurology·Jonathan K KleenBarbara C Jobst
May 28, 2013·NeuroImage·R Matthew HutchisonCatie Chang
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Maria TalantovaStuart A Lipton
Jul 10, 2013·JAMA Neurology·Keith A VosselLennart Mucke
Sep 3, 2013·NeuroImage·Jonathan D PowerSteven E Petersen
Nov 13, 2013·Neurobiology of Aging·Matthew R BrierBeau M Ances
Feb 20, 2014·Frontiers in Systems Neuroscience·Xiao LiuJeff H Duyn
May 6, 2014·Neurobiology of Aging·Vered KellnerEdward A Stern
Jul 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrew ZaleskyMichael Breakspear
Sep 23, 2014·NeuroImage·Nora Leonardi, Dimitri Van De Ville
Nov 13, 2014·Frontiers in Neurology·Nahla L FaizoDavid Reutens

❮ Previous
Next ❯

Citations

Jun 12, 2021·NeuroImage·S G Mueller, A M Muller

❮ Previous
Next ❯

Software Mentioned

SimTB
DARTEL
ART
SPM
aCompCorr
AICHA
SPM12

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.