Abstract
Animal studies have shown that cerebral hypoperfusion may be associated with amyloid plaque accumulation. Amyloid plaque is known to be associated with dementia and [(18)F]AV-45 is a positron emission tomography (PET) ligand that binds to extracelluar plaques. We hypothesized that demented patients with cerebral hypoperfusion may have increased [(18)F]AV-45 uptake. Five demented patients with cerebral hypoperfusion due to unilateral carotid artery stenosis (CAS) were examined with [(18)F]AV-45 PET, and the results were compared with six elderly controls. The standard uptake value ratio (SUVR) of each region of interest (ROI) was created using whole cerebellum as the reference region. All subjects underwent magnetic resonance imaging (MRI) for obtaining structural information. Patients with dementia and unilateral CAS had a higher global [(18)F]AV-45 SUVR (1.34 ± 0.06) as compared with controls (1.10 ± 0.04, p=0.0043), especially over the frontal, temporal, precuneus, anterior cingulate and occipital regions. The statistical distribution maps revealed a significantly increased [(18)F]AV-45 SUVR in the medial frontal, caudate, thalamus, posterior cingulate, occipital and middle and superior temporal regions ipsilateral to the sid...Continue Reading
References
Aug 15, 1991·The New England Journal of Medicine·UNKNOWN North American Symptomatic Carotid Endarterectomy Trial CollaboratorsM Eliasziw
Feb 1, 1993·Neurology·G C RománA Hofman
Mar 12, 1997·JAMA : the Journal of the American Medical Association·D A SnowdonW R Markesbery
Oct 28, 1997·Stroke; a Journal of Cerebral Circulation·W I Rosenblum
Dec 28, 1999·Alzheimer Disease and Associated Disorders·R N Kalaria, C Ballard
Jun 13, 2000·Alzheimer Disease and Associated Disorders·J C de la Torre
Feb 27, 2001·Neurology·K A KnudsenS M Greenberg
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·L O WahlundUNKNOWN European Task Force on Age-Related White Matter Changes
Jan 5, 2002·NeuroImage·N Tzourio-MazoyerM Joliot
Jun 2, 2005·Annals of Neurology·Annemieke RuitenbergMonique M B Breteler
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Jul 15, 2005·Radiology·Aart SpiltRudi G J Westendorp
Nov 23, 2005·Neurobiology of Aging·Gustavo C Román, Raj N Kalaria
Apr 8, 2006·Neuropathology and Applied Neurobiology·H LewisR N Kalaria
Oct 27, 2006·Neurology·P EdisonD J Brooks
Feb 6, 2007·Vascular and Endovascular Surgery·Brajesh K Lal
Jun 15, 2007·Neurology·Julie A SchneiderDavid A Bennett
Aug 30, 2008·Stroke; a Journal of Cerebral Circulation·Paola De RangoPiergiorgio Cao
Jan 9, 2010·Journal of the Neurological Sciences·Vincent MokKa Sing Wong
Feb 10, 2010·Neurology·J V LyC C Rowe
May 8, 2010·Nuclear Medicine and Biology·Kun-Ju LinMei-Ping Kung
May 18, 2010·Neurobiology of Aging·Christopher C RoweVictor L Villemagne
May 18, 2010·The American Journal of Pathology·Maya A KoikeFrank M Laferla
Jun 28, 2011·AJNR. American Journal of Neuroradiology·S XieQ Peng
Citations
Aug 13, 2013·Journal of Neural Transmission·Amos D Korczyn
Mar 22, 2013·PloS One·Kuo-Lun HuangChin-Chang Huang
Jun 15, 2013·Beilstein Journal of Organic Chemistry·Todd J EckroatSylvie Garneau-Tsodikova
Mar 13, 2014·Revue neurologique·K MuraoD Leys
Sep 18, 2012·FEBS Letters·Minjie TianJingping Shi
Nov 12, 2013·Journal of the Neurological Sciences·Kuo-Lun HuangMeng-Yang Ho
Mar 23, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Austyn RoseboroughJodi D Edwards
Jan 16, 2016·Biochimica Et Biophysica Acta·A Kapasi, J A Schneider
May 4, 2017·Journal of Neuroscience Research·Crystal AcostaChristopher M Anderson
Aug 25, 2017·Neurochemical Research·Zhiyou CaiFuming Tian
Jul 10, 2014·Stroke; a Journal of Cerebral Circulation·Alexander ThielShawn N Whitehead
Nov 19, 2015·Stroke; a Journal of Cerebral Circulation·Ramesh SahathevanAmy Brodtmann
Mar 11, 2018·Neurology·M Fareed K SuriBruce A Wasserman
Mar 15, 2015·Stroke; a Journal of Cerebral Circulation·Wenyan LiuVincent C T Mok
Aug 29, 2016·Journal of Alzheimer's Disease : JAD·Young NohDuk L Na
Feb 15, 2018·Journal of Alzheimer's Disease : JAD·Chiho ShodaYoshiro Okubo
Dec 11, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M BraininUNKNOWN Post Stroke Cognition Study Group
Sep 23, 2018·Neuromolecular Medicine·Sung-Chun TangJiann-Shing Jeng
Sep 12, 2020·Alzheimer's Research & Therapy·Koung Mi KangUNKNOWN KBASE Research Group