Amyloid imaging of dutch-type hereditary cerebral amyloid angiopathy carriers

Annals of Neurology
Aaron P SchultzSteven M Greenberg

Abstract

To determine whether amyloid imaging with the positron emission tomography (PET) agent Pittsburgh compound B (PiB) can detect vascular β-amyloid (Aβ) in the essentially pure form of cerebral amyloid angiopathy associated with the Dutch-type hereditary cerebral amyloid angiopathy (D-CAA) mutation. PiB retention in a cortical composite of frontal, lateral, and retrosplenial regions (FLR) was measured by PiB-PET in 19 D-CAA mutation carriers (M+ ; 13 without neurologic symptoms, 6 with prior lobar intracerebral hemorrhage) and 17 mutation noncarriers (M- ). Progression of PiB retention was analyzed in a subset of 18 serially imaged individuals (10 asymptomatic M+ , 8 M- ). We also analyzed associations between PiB retention and cerebrospinal fluid (CSF) Aβ concentrations in 17 M+ and 11 M- participants who underwent lumbar puncture and compared the findings to PiB-PET and CSF Aβ in 37 autosomal dominant Alzheimer disease (ADAD) mutation carriers. D-CAA M+ showed greater age-dependent FLR PiB retention (p < 0.001) than M- , and serially imaged asymptomatic M+ demonstrated greater longitudinal increases (p = 0.004). Among M+ , greater FLR PiB retention associated with reduced CSF concentrations of Aβ40 (r = -0.55, p = 0.021) but not...Continue Reading

References

Apr 15, 2006·Brain Pathology·Sandy X Zhang-NunesSteven M Greenberg
Aug 9, 2007·Annals of Neurology·Keith A JohnsonSteven M Greenberg
Dec 11, 2008·Annals of Neurology·Steven M GreenbergKeith A Johnson
Feb 19, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Rebecca L McNameeChester A Mathis
Jun 27, 2009·Stroke; a Journal of Cerebral Circulation·Sanneke van RoodenMark A van Buchem
Sep 11, 2009·Annals of Neurology·Marcel M VerbeekSteven M Greenberg
Nov 17, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hedy FolkersmaBart N M van Berckel
Sep 25, 2010·Annals of Neurology·Gregory A DierksenSteven M Greenberg
Jul 13, 2012·The New England Journal of Medicine·Randall J BatemanUNKNOWN Dominantly Inherited Alzheimer Network
Nov 7, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tammie L S BenzingerJohn C Morris
Mar 7, 2014·Science Translational Medicine·Anne M FaganUNKNOWN Dominantly Inherited Alzheimer Network
Apr 22, 2014·Neurology·Elizabeth C MorminoUNKNOWN Harvard Aging Brain Study
Jun 6, 2014·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Marissa D ZwanBart N M van Berckel
Aug 8, 2015·Neurology·Fen WangUNKNOWN Dominantly Inherited Alzheimer Network
Oct 28, 2015·Annals of Neurology·Keith A JohnsonReisa Sperling
Jul 31, 2016·Neurology·Jasmeer P ChhatwalKeith A Johnson
Sep 2, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Randall J BatemanUNKNOWN DIAN-TU Pharma Consortium for the Dominantly Inherited Alzheimer Network
Sep 9, 2016·Neurology·M Edip GurolSteven M Greenberg
Nov 12, 2016·Stroke; a Journal of Cerebral Circulation·Sanneke van RoodenMark A van Buchem
Dec 3, 2016·Neurology·Ellis S van EttenGisela M Terwindt
Sep 1, 2017·Neurology·Andreas CharidimouJean-Claude Baron
Nov 10, 2017·Current Opinion in Neurology·Marieke J H Wermer, Steven M Greenberg

❮ Previous
Next ❯

Citations

Jun 13, 2019·Arquivos de neuro-psiquiatria·Ayrton R Massaro, Alexandre Pieri
May 18, 2020·International Journal of Molecular Sciences·Laura GattiAnna Bersano
Aug 19, 2020·The Journal of Infectious Diseases·Andrew N BubakMaria A Nagel
Dec 1, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Mariel G KozbergSusanne J van Veluw
Dec 29, 2020·Journal of Alzheimer's Disease : JAD·Pratishtha ChatterjeeUNKNOWN Dominantly Inherited Alzheimer Network
Jan 28, 2021·Journal of the Neurological Sciences·Teresa MescherMaria A Nagel
Mar 21, 2021·Lancet Neurology·Steven M Greenberg
Apr 4, 2021·International Journal of Molecular Sciences·Pratishtha Chatterjee The Dominantly Inherited Alzheimer Network
Jun 1, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Lieke JäkelMarcel M Verbeek
Aug 17, 2021·Radiologic Clinics of North America·Christian MasonJason S Lewis
Sep 11, 2021·Neurology·Stuart J McCarterJonathan Graff-Radford

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.