Amyloid imaging using fluorine-19 magnetic resonance imaging ((19)F-MRI)

Ageing Research Reviews
Ikuo TooyamaShigehiro Morikawa

Abstract

The formation of senile plaques followed by the deposition of amyloid-β is the earliest pathological change in Alzheimer's disease. Thus, the detection of senile plaques remains the most important early diagnostic indicator of Alzheimer's disease. Amyloid imaging is a noninvasive technique for visualizing senile plaques in the brains of Alzheimer's patients using positron emission tomography (PET) or magnetic resonance imaging (MRI). Because fluorine-19 ((19)F) displays an intense nuclear magnetic resonance signal and is almost non-existent in the body, targets are detected with a higher signal-to-noise ratio using appropriate fluorinated contrast agents. The recent introduction of high-field MRI allows us to detect amyloid depositions in the brain of living mouse using (19)F-MRI. So far, at least three probes have been reported to detect amyloid deposition in the brain of transgenic mouse models of Alzheimer's disease; (E,E)-1-fluoro-2,5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (FSB), 1,7-bis(4'-hydroxy-3'-trifluoromethoxyphenyl)-4-methoxycarbonylethyl-1,6-heptadiene3,5-dione (FMeC1, Shiga-Y5) and 6-(3',6',9',15',18',21'-heptaoxa-23',23',23'-trifluorotricosanyloxy)-2-(4'-dimethylaminostyryl)benzoxazole (XP7, Shiga-X22). ...Continue Reading

References

Apr 10, 1992·Science·J A Hardy, G A Higgins
Jan 16, 2002·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Kooresh Shoghi-JadidJorge R Barrio
May 11, 2002·International Psychogeriatrics·C J VasS Sachdeva
Feb 3, 2005·The British Journal of Psychiatry : the Journal of Mental Science·S ShajiAbraham Verghese
Jul 26, 2005·Nature Biotechnology·Eric T AhrensPenelope A Morel
Aug 11, 2006·Neuroscience Research·Chiaki MasudaIkuo Tooyama
Feb 8, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kathryn C PartlowSamuel A Wickline
Mar 8, 2008·Cellular and Molecular Life Sciences : CMLS·H HatcherS V Torti
Dec 1, 2009·Journal of Neurology·Katsutoshi FurukawaHiroyuki Arai
Jan 20, 2010·Lancet Neurology·Clifford R JackJohn Q Trojanowski
Oct 5, 2010·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Tomone AmatsuboIkuo Tooyama
Jan 20, 2011·JAMA : the Journal of the American Medical Association·Christopher M ClarkUNKNOWN AV45-A07 Study Group
Jul 13, 2012·The New England Journal of Medicine·Randall J BatemanUNKNOWN Dominantly Inherited Alzheimer Network

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Citations

Apr 2, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Derek DustinRobia G Pautler
Oct 25, 2017·Journal of Neuroscience Research·Daijiro YanagisawaIkuo Tooyama
Sep 28, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·S LacerdaÉ Tóth
Mar 29, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Rob C I WüstGustav J Strijkers
Apr 1, 2016·Journal of Alzheimer's Disease : JAD·Eric A TanifumAnanth Annapragada
Aug 7, 2020·Organic & Biomolecular Chemistry·Ryo KakiuchiHideko Nagasawa
Nov 28, 2018·Inflammation and Regeneration·Hirohito IshigakiKazumasa Ogasawara

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