Amyloid-like formation by self-assembly of peptidolipids in two dimensions

Langmuir : the ACS Journal of Surfaces and Colloids
Changqing LiRoger M Leblanc

Abstract

The accumulation of beta-amyloid peptide (Abeta) in the human brain is known to be the major cause that drives Alzheimer's disease pathogenesis. Abeta, a 39-42 amino acid peptide, is the cleavage product of amyloid precursor protein in the hydrophobic transmembrane region. The present study employs a two-dimensional (2D) approach. Two synthetic peptidolipids, C18-IIGLM-OH and C18-IIGLM-NH2, are selected based on the fragment 31-35 of Abeta which is recognized as one of the determining segments that induces formation of amyloid fibril plaques. The aliphatic hydrocarbon chain C18 is attached to the N-terminal of the fragment 31-35 to facilitate the 2D study at the air-water interface. The aggregation process is observed by two measurements: (1) surface pressure-area and surface dipole moment-area isotherms and (2) epifluorescence microscopy of the Langmuir films to investigate the topography of the amyloid-like formation.

References

Apr 1, 1991·Neuron·D J Selkoe
Mar 5, 1991·Journal of Molecular Biology·C HilbichK Beyreuther
Mar 1, 1990·International Journal of Peptide and Protein Research·G B Fields, R L Noble
Jan 1, 1994·Annual Review of Neuroscience·D J Selkoe
Aug 2, 1996·The Journal of Biological Chemistry·D J Selkoe
Nov 14, 1997·Journal of Molecular Biology·M SundeC C Blake
Aug 1, 1998·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·D B Teplow
Jan 6, 2004·Journal of Neuroscience Research·Ruitian LiuMichael R Sierks

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Citations

Oct 18, 2006·The Journal of Chemical Physics·Jack F DouglasKarl F Freed
Sep 4, 2009·Colloids and Surfaces. B, Biointerfaces·Garima ThakurRoger M Leblanc
Dec 6, 2008·Chemistry and Physics of Lipids·Annalisa ReliniAlessandra Gliozzi
Oct 16, 2007·Angewandte Chemie·Ian W Hamley
Aug 6, 2005·Biochemical and Biophysical Research Communications·Norbert W Seidler, Trevor J Squire
May 9, 2006·Medical Hypotheses·N W SeidlerT J Squire
Jan 30, 2020·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·John M Sanderson
Jan 17, 2008·The Journal of Physical Chemistry. B·Takeshi HasegawaRoger M Leblanc
Jun 3, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Jingjing LaiYanbin Huang

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