Amyloid Peptide Mixtures: Self-Assembly, Hydrogelation, Nematic Ordering, and Catalysts in Aldol Reactions

Langmuir : the ACS Journal of Surfaces and Colloids
Juliane N B D PelinW A Alves

Abstract

Morphological, spectroscopic, and scattering studies of the self-assembly and aggregation of mixtures of [RF]4 and P[RF]4 peptides (where R = arginine; F = phenylalanine; P = proline), in solution and as hydrogels, were performed to obtain information about polymorphism. CD data confirmed a β-sheet secondary structure in aqueous solution, and TEM images revealed nanofibers with diameters of ∼10 nm and micrometer lengths. SAXS curves were fitted using a mass fractal-component and a long cylinder shell form factor for the liquid samples, and only a long cylinder shell form factor for the gels. Increasing the P[RF]4 content in the systems leads to a reduction in cylinder radius and core scattering density, suggesting an increase in packing of the peptide molecules; however, the opposite effect is observed for the gels, where the scattering density is higher in the shell for the systems containing higher P[RF]4 content. These compounds show potential as catalysts in the asymmetric aldol reactions, with cyclohexanone and p-nitrobenzaldehyde in aqueous media. A moderate conversion (36.9%) and a good stereoselectivity (69:31) were observed for the system containing only [RF]4. With increasing P[RF]4 content, a considerable decrease of...Continue Reading

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Citations

Sep 3, 2020·Journal of Synchrotron Radiation·Nathan P CowiesonRobert P Rambo
Apr 13, 2021·Biomacromolecules·Ian W Hamley
Jul 20, 2021·Chemical Communications : Chem Comm·Sumit PalDibyendu Das
Aug 17, 2021·Frontiers in Chemistry·Patrizia JankovićDaniela Kalafatovic
Aug 24, 2021·Current Opinion in Chemical Biology·Liam R Marshall, Ivan V Korendovych

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Methods Mentioned

BETA
electron microscopy
Transmission
X-ray
NMR
rheometry
rheology

Software Mentioned

SASfit
ScÅtter

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